High expression of FMNL1 protein in T non-Hodgkin's lymphomas

We recently cloned a novel Formin-family human gene, denominated human leukocyte formin and posteriorly named as FMNL1 by the HUGO Gene Nomenclature Committee. This gene is overexpressed in lymphoid malignances and is found associated with Akt. Here, we describe the expression of the FMNL1 protein i...

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Published inLeukemia research Vol. 30; no. 6; pp. 735 - 738
Main Authors Favaro, Patricia M.B., Traina, Fabiola, Vassallo, Jose, Brousset, Pierre, Delsol, George, Costa, Fernando F., Saad, Sara T.O.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2006
Subjects
Adult
Aged
Aged, 80 and over
Blotting, Western
Cytoskeletal Proteins - biosynthesis
Cytoskeletal Proteins - genetics
Female
FMNL1
Gene Expression Regulation, Leukemic - genetics
Human leukocyte formin
Humans
KW-13
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphoma, T-Cell - genetics
Lymphoma, T-Cell - metabolism
Lymphoma, T-Cell - pathology
Male
Middle Aged
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Non-Hodgkin's lymphomas
FMNL1
KW-13
Non-Hodgkin's lymphomas
Human leukocyte formin
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Summary:We recently cloned a novel Formin-family human gene, denominated human leukocyte formin and posteriorly named as FMNL1 by the HUGO Gene Nomenclature Committee. This gene is overexpressed in lymphoid malignances and is found associated with Akt. Here, we describe the expression of the FMNL1 protein in 54 frozen biopsies of non-Hodgkin's lymphoma (NHL) patients and five reactive lymph nodes. Western blot analysis revealed expression of FMNL1 in all samples studied, although the highest expression was in T-cell NHL ( P < 0.05).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2005.10.003