Bamboo leave extract ameliorated 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ear inflammation by reducing MAP kinase levels and NF-κB activation in mice model

• Published in: Natural product research Vol. 35; no. 23; pp. 5299 - 5303
• Main Authors: Khan, Imran, Dey, Debasish Kumar, Lee, Jai-Heon, Kang, Sun Chul
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.12.2021; Taylor & Francis Ltd
• Subjects: 12-O-Tetradecanoylphorbol-13-acetate; Acetic acid; Bamboo; Chemical compounds; Ear; ear edema; Edema; Herbal medicine; Inflammation; Kinases; MAP kinase; Medicinal plants; NF-κB protein; Pharmacology; Proteins; SCN; Signal transduction; Skin; TPA; Transcription activation; ear edema; TPA; inflammation; SCN
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2020.1753053

Sasa coreana Nakai (SCN) is a medicinal plant commonly used against inflammation. However, the underlined mechanisms against skin inflammation is poorly understood. The present study investigated the effects of SCN leave extract on ear inflammation. To this aim, six-week-old male ICR mice was subjected to 12-O-tetradecanoyl-phorbol-13-acetate induce ear edema, which were then topically treated with the leave extract of SCN. Ear thickness, weight, and morphological changes were recorded to ensure the induction of ear edema. Further, histological analysis and protein expression for inflammatory markers were also recorded to validate the study. Topical treatment with SCN repressed TPA-induced ear edema in a dose-dependent manner. Further, SCN treatment significantly antagonized the protein expression of MAP kinase signaling pathway and reduced the effect of TPA-induced NF-κB activation, sequentially, deactivated its transcriptional targets in a dose-dependent manner. Collectively, the study suggested that SCN could be a useful therapeutic agent against skin inflammation.