Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart

• Published in: Circulation (New York, N.Y.) Vol. 94; no. 11; pp. 2831 - 2836
• Main Authors: VAN DOBBENBURGH, J. O, LAHPOR, J. R, WOOLLEY, S. R, DE JONGE, N, KLÖPPING, C, VAN ECHTELD, C. J. A
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.1996; American Heart Association, Inc
• Subjects: Adolescent; Adult; Biological and medical sciences; Cardiac Output; Cryopreservation; Energy Metabolism; Female; Heart - physiopathology; Heart Transplantation; Humans; Male; Medical sciences; Middle Aged; Myocardial Reperfusion; Myocardium - metabolism; Phosphates - metabolism; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Time Factors; Heart; Human; Spectrometry; High energy phosphate; Treatment; Surgery; Magnetic resonance; Exploration; Induced hypothermia; Transplantation; Homotransplantation; Metabolism
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.94.11.2831

Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplantation may be of great value. In the present study, the energy metabolism of 25 excised human donor hearts arrested with St Thomas' Hospital No. 2 cardioplegic solution was evaluated noninvasively by use of 31P magnetic resonance spectroscopy (MRS) before implantation and was correlated with myocardial function measured with thermodilution in heart transplant patients. No significant correlation was observed between the cardiac index of heart transplant patients during the first hours after transplantation and the phosphocreatine/ATP (r = .13, P = .54), inorganic phosphate/ATP (r = .26, P = .21), phosphomonoesters/ATP (r = .02, P = .92), or phosphocreatine/inorganic phosphate (r = .16, P = .44) ratio or the intracellular pH (r = .06, P = .78) at the time of reperfusion. However, 1 week after transplantation, a significant correlation was observed between the cardiac index and the phosphocreatine/ATP (r = .49, P = .01), phosphomonoesters/ATP (r = .45, P = .02), and phosphocreatine/inorganic phosphate (r = .40, P = .05) ratios at the time of reperfusion. In contrast, the inorganic phosphate/ATP (r = .10, P = .63) ratio and pH (r = .31, P = .13) at the time of reperfusion showed a poor correlation with the cardiac index 1 week after transplantation. Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart.