Inhibition of specific immune responses by feeding protein antigens

• Published in: International archives of allergy and applied immunology Vol. 55; no. 1-6; p. 526
• Main Authors: Hanson, D G, Vaz, N M, Maia, L C, Hornbrook, M M, Lynch, J M, Roy, C A
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.1977
• Subjects: Administration, Oral; Animals; Antibody Formation; Antigens - administration & dosage; Dinitrobenzenes - administration & dosage; Female; Hemocyanins - administration & dosage; Immune Tolerance; Injections, Intraperitoneal; Injections, Intravenous; Intubation, Gastrointestinal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ovalbumin - administration & dosage; Ovomucin - administration & dosage

A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achi...