Inhibition of specific immune responses by feeding protein antigens

A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achi...

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Bibliographic Details
Published inInternational archives of allergy and applied immunology Vol. 55; no. 1-6; p. 526
Main Authors Hanson, D G, Vaz, N M, Maia, L C, Hornbrook, M M, Lynch, J M, Roy, C A
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1977
Subjects
Administration, Oral
Animals
Antibody Formation
Antigens - administration & dosage
Dinitrobenzenes - administration & dosage
Female
Hemocyanins - administration & dosage
Immune Tolerance
Injections, Intraperitoneal
Injections, Intravenous
Intubation, Gastrointestinal
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Ovalbumin - administration & dosage
Ovomucin - administration & dosage
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Summary:A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achieved by intravenous injection of deaggregated ovalbumin solutions across a wide range of doses. Unresponsiveness induced by intragastric exposure to hapten-protein conjugates is specific to the carrier protein.
ISSN:0020-5915
DOI:10.1159/000231966