Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

• Published in: International journal of food sciences and nutrition Vol. 70; no. 8; pp. 977 - 985
• Main Authors: Quezada-Fernández, Patricia, Trujillo-Quiros, Jhonatan, Pascoe-González, Sara, Trujillo-Rangel, Walter A., Cardona-Müller, David, Ramos-Becerra, Carlos G., Barocio-Pantoja, Maricruz, Rodríguez-de la Cerda, Mariana, Nérida Sánchez-Rodríguez, Esther, Cardona-Muñóz, Ernesto G., García-Benavides, Leonel, Grover-Páez, Fernando
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.11.2019; Taylor & Francis Ltd
• Subjects: Adult; Advanced glycosylation end products; Alanine Transaminase - blood; arterial stiffness; Arteriosclerosis; Aspartate Aminotransferases - blood; Atherosclerosis; Blood vessels; Body composition; Body Composition - drug effects; Body Mass Index; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Creatinine - blood; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Dietary Supplements; Double-Blind Method; Double-blind studies; Epigallocatechin gallate; Female; Food science; Glycated Hemoglobin A - metabolism; Glycosylation; Green tea; Green tea extract; Hemodynamics - drug effects; Hormone replacement therapy; Humans; Lipid Metabolism - drug effects; lipid profile; Lipids; Male; Middle Aged; Placebo effect; Plant Extracts - pharmacology; Polyphenols; Polyphenols - administration & dosage; Randomization; Receptor for Advanced Glycation End Products - blood; S100 Proteins - blood; sRAGE; Statins; Stiffening; Stiffness; Tea; Tea - chemistry; Therapy; Triglycerides - blood; type 2 diabetes mellitus; Vascular Stiffness - drug effects; arterial stiffness; type 2 diabetes mellitus; Green tea extract; polyphenols; sRAGE; lipid profile
• ISSN: 0963-7486; 1465-3478
• DOI: 10.1080/09637486.2019.1589430

Type 2 diabetes mellitus (T2DM) is associated with premature atherosclerosis and arterial stiffening due to the accumulation of advanced glycation end-products in vessel walls. Green tea polyphenols are considered cardio-protective substances. In this randomised double-blind placebo-controlled trial (NCT02627898), we evaluated the effect of Green tea extract on arterial stiffness parameters, lipids, body composition and sRAGE levels. Twenty normotensive patients with T2DM treated with the standard therapy and statins, mean age 53.2 ± 9.4 years and mean BMI 30.1 ± 4.5 kg/m 2 , were randomised to receive a daily dose of 400 mg of green tea extract (polyphenols ≥90%, EGCG ≥45%) or placebo for 12 weeks. Compared to placebo, administration of green tea extract decreased central augmentation index (-3.05 ± 10.8% vs. 6.7 ± 0.1%, p = .04). These findings suggest that green tea extract could be used as an adjunct to the standard therapy to improve arterial stiffness in T2DM.