Hepatic arterial infusion chemotherapy with a coaxial reservoir system using a non-braided spiral tip microcatheter

• Published in: Japanese journal of radiology Vol. 30; no. 1; pp. 10 - 17
• Main Authors: Koganemaru, Masamichi, Abe, Toshi, Iwamoto, Ryoji, Nonoshita, Masaaki, Yoshida, Seigo, Uchiyama, Daiji, Hayabuchi, Naofumi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.01.2012; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic - administration & dosage; Carcinoma, Hepatocellular - drug therapy; Catheters, Indwelling; Cisplatin - administration & dosage; Female; Fluorouracil - administration & dosage; Follow-Up Studies; Hepatic Artery; Humans; Imaging; Infusions, Intra-Arterial - instrumentation; Infusions, Intra-Arterial - methods; Liver Neoplasms - drug therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Radiology; Radiotherapy; Retrospective Studies; Treatment Outcome; Coaxial reservoir; Exclusive port; Microcatheter; Hepatic arterial infusion chemotherapy
• ISSN: 1867-1071; 1867-108X
• DOI: 10.1007/s11604-011-0001-3

Purpose To evaluate the efficacy and safety of a coaxial reservoir system with a non-braided spiral tip microcatheter and exclusive port for hepatic arterial infusion chemotherapy. Materials and methods In vitro evaluation included evaluation of pressure tolerance/flow rate of the coaxial reservoir system, and the strength of connection between the 2.7-F catheter and port. Due to the difficulty of implanting conventional reservoirs, coaxial reservoirs were implanted via the femoral artery of 80 patients. We implanted a non-braided 2.7-F microcatheter with a spiral shaped tip, 5-F catheter, and a port. Clinical assessment included evaluation of technical success and complications. Results In vitro evaluation of the coaxial reservoir at its maximum pressure load showed that flow rates for 300 mg I/mL iopamidol contrast medium were 0.25 ± 0.04 mL/s (undiluted), 1.03 ± 0.01 mL/s (50% dilution), and 2.91 ± 0.01 mL/s (30% dilution). Connection strength between the 2.7-F catheter and port was 13.4 ± 0.57 N. Percutaneous port catheter placement was successful in all patients (100%, n  = 80). Complications included hepatic arterial occlusion (10%, n  = 8), catheter tip dislocation (1.3%, n  = 1), and catheter occlusion (1.3%, n  = 1). Conclusions A coaxial reservoir system with a non-braided microcatheter and exclusive port is safe and effective for difficulty of implanting conventional reservoir.