In vivo dynamic optical coherence elastography using a ring actuator

We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were...

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Bibliographic Details
Published inOptics express Vol. 17; no. 24; p. 21762
Main Authors Kennedy, Brendan F., Hillman, Timothy R., McLaughlin, Robert A., Quirk, Bryden C., Sampson, David D.
Format Journal Article
LanguageEnglish
Published United States 23.11.2009
Subjects
Adult
Algorithms
Elasticity Imaging Techniques - instrumentation
Elasticity Imaging Techniques - methods
Equipment Design
Humans
Image Interpretation, Computer-Assisted - methods
Interferometry - methods
Male
Phantoms, Imaging
Scattering, Radiation
Skin - pathology
Tomography, Optical Coherence - methods
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Summary:We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were coupled to samples that were imaged using optical coherence tomography. The resulting vibration amplitude and microstrain maps are presented for bilayer silicone phantoms and multiple skin sites on a human subject. Contrast based on the differing elastic properties is shown, notably between the epidermis and dermis. The results constitute the first demonstration of a practical means of performing in vivo dynamic optical coherence elastography on a human subject.
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ISSN:1094-4087
1094-4087
DOI:10.1364/OE.17.021762