Effect of Oxidation-Modified Fibrinogen on the Formation and Lysis of Fibrin Clot in the Plasma

Turbidimetry studies showed that after addition of thrombin to fresh donor plasma light scatter in the sample increases and slowly attains a plateau. The process of fibrin formation was less intensive in the presence of oxidized fibrinogen. The formation of fibrin clot in lyophilized plasma was char...

Full description

Saved in:
Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 148; no. 6; pp. 881 - 883
Main Authors Piryazev, A. P, Aseichev, A. V, Azizova, O. A
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.12.2009
Springer US
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Fibrin - metabolism
fibrinogen
Fibrinogen - metabolism
Humans
Internal Medicine
Laboratory Medicine
Nephelometry and Turbidimetry
Oxidative Stress
Pathology
Plasma - metabolism
Streptokinase - metabolism
Thrombin - metabolism
turbidimetry
turbidimetry
fibrinogen
oxidative stress
Online AccessGet full text

Cover

More Information
Summary:Turbidimetry studies showed that after addition of thrombin to fresh donor plasma light scatter in the sample increases and slowly attains a plateau. The process of fibrin formation was less intensive in the presence of oxidized fibrinogen. The formation of fibrin clot in lyophilized plasma was characterized by a biphasic kinetic of light scatter, oxidized fibrinogen inhibited both phases of the process. In the presence of streptokinase, oxidized fibrinogen did not modify the kinetics of fibrin clot lysis. Addition of oxidized fibrinogen to plasma reduced optical density of fibrin clot the more intensely the higher was the degree of oxidative modification of fibrinogen.
Bibliography:http://dx.doi.org/10.1007/s10517-010-0841-3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0841-3