Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles

A novel multicomponent reaction of isocyanides with thiophenols and gem-diactivated olefins has been discovered. Depending on the choice of isocyanides, substituted 2-aminopyrroles or thioimidates have been prepared. The obtained scaffolds bearing four points of diversity can directly be used in com...

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Published inMolecular diversity Vol. 14; no. 3; pp. 543 - 550
Main Authors Kolontsova, Anna N, Ivantsova, Maria N, Tokareva, Maria I, Mironov, Maxim A
Format Journal Article
LanguageEnglish
Published Dordrecht Dordrecht : Springer Netherlands 01.08.2010
Springer Netherlands
Springer Nature B.V
Subjects
2-Aminopyrroles
Alkenes - chemistry
Biochemistry
Biomedical and Life Sciences
Chemical reactions
Chemical synthesis
Chemistry, Organic - methods
Combinatorics
Cyanides - chemistry
Isocyanides
Life Sciences
MCRs
Multicomponent
Organic Chemistry
Pharmacy
Phenols - chemistry
Polymer Sciences
Pyrroles - chemical synthesis
Pyrroles - chemistry
Reaction design
Sulfhydryl Compounds - chemistry
Thioimidates
2-Aminopyrroles
Reaction design
MCRs
Multicomponent
Isocyanides
Thioimidates
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Summary:A novel multicomponent reaction of isocyanides with thiophenols and gem-diactivated olefins has been discovered. Depending on the choice of isocyanides, substituted 2-aminopyrroles or thioimidates have been prepared. The obtained scaffolds bearing four points of diversity can directly be used in combinatorial syntheses.
Bibliography:http://dx.doi.org/10.1007/s11030-010-9233-x
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-010-9233-x