Three new tetralol analogs from soil-derived fungus Myrothecium verrucaria with anti-inflammatory activity

• Published in: Journal of asian natural products research Vol. 21; no. 1; pp. 33 - 42
• Main Authors: Liu, Lu, Tang, Ming-Xu, Sang, Xia-Nan, Chen, Shao-Fei, Lu, Xiao-Jie, Wang, Yu-Bo, Si, Ying-Ying, Wang, Hai-Feng, Chen, Gang, Pei, Yue-Hu
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 02.01.2019; Taylor & Francis Ltd
• Subjects: Analogs; anti-inflammation; Anti-Inflammatory Agents - pharmacology; Antiinflammatory agents; Chemistry; Chemistry, Applied; Chemistry, Medicinal; Cytotoxicity; Fungi; HL-60 Cells; Humans; Hypocreales - metabolism; Inflammation; Life Sciences & Biomedicine; Lipopolysaccharides; Myrothecium verrucaria; NMR; Nuclear magnetic resonance; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Science & Technology; Soil Microbiology; Soil microorganisms; Tetralol analogs; Tetralones - chemistry; Tetralones - isolation & purification; Tetralones - pharmacology; Toxicity; Trichothecenes; RORIDINS; Tetralol analogs; TRICHOVERROIDS; anti-inflammation; Myrothecium verrucaria; MACROCYCLIC TRICHOTHECENES; DERIVATIVES; cytotoxicity
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2018.1439934

Three new tetralol analogs, myrochromanols A-C (1-3), together with 11 known trichothecenes (4-14), were isolated from a soil fungus Myrothecium verrucaria HL-P-1. The structures of the three new compounds were elucidated by extensive spectroscopic analysis including HRESIMS, NMR, and ECD calculation. All of the new compounds were tested for their anti-inflammatory activity and cytotoxicity. Compounds 1 and 3 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells with IC 50 values of 26.04 and 25.80 μM, respectively. Three new tetralol analogs were isolated from a soil fungus Myrothecium verrucaria HL-P-1. All of them were tested for their anti-inflammatory and cytotoxicity activity.