Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation

Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobo...

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Published inJournal of asian natural products research Vol. 19; no. 5; pp. 510 - 518
Main Authors Tuan Anh, Hoang Le, Tuan, Do Thanh, Trang, Do Thi, Tai, Bui Huu, Nhiem, Nguyen Xuan, Yen, Pham Hai, Kiem, Phan Van, Minh, Chau Van, Duc, Tran Minh, Kang, Hee Kyoung, Kim, Youn Chul, Kim, Young Ho
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 01.05.2017
Taylor & Francis Ltd
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
anti-leukemia
Chemistry
Chemistry, Applied
Chemistry, Medicinal
cudraisoflavone L
Cudrania tricuspidata
Cytoprotection - drug effects
HL-60 Cells
Humans
Isoflavones - chemistry
Isoflavones - isolation & purification
Isoflavones - pharmacology
Life Sciences & Biomedicine
Macrophages - drug effects
Mice
Molecular Structure
Moraceae - chemistry
Nitric Oxide - biosynthesis
NO inhibitor
Pharmacology & Pharmacy
Physical Sciences
Plant Roots - chemistry
Plant Sciences
Prenylated isoflavone
Prenylation
Science & Technology
FRUITS
NO inhibitor
cudraisoflavone L
BARK
ROOTS
FLAVONOIDS
ERYTHRINA
Prenylated isoflavone
Cudrania tricuspidata
anti-leukemia
XANTHONES
EXTRACT
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Abstract Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC 50 4.3 ± 0.7 to 18.0 ± 1.7 μM).
AbstractList Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 μM).
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC 50 4.3 ± 0.7 to 18.0 ± 1.7 μM).
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC 4.3 ± 0.7 to 18.0 ± 1.7 μM).
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10M, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 +/- 2.4, 66.9 +/- 1.8, and 55.4 +/- 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC50 4.3 +/- 0.7 to 18.0 +/- 1.7M).
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 μM).
Author Nhiem, Nguyen Xuan
Tuan Anh, Hoang Le
Kiem, Phan Van
Kang, Hee Kyoung
Trang, Do Thi
Yen, Pham Hai
Duc, Tran Minh
Kim, Youn Chul
Tuan, Do Thanh
Tai, Bui Huu
Minh, Chau Van
Kim, Young Ho
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Issue 5
Keywords FRUITS
NO inhibitor
cudraisoflavone L
BARK
ROOTS
FLAVONOIDS
ERYTHRINA
Prenylated isoflavone
Cudrania tricuspidata
anti-leukemia
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EXTRACT
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Snippet Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and...
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SubjectTerms Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
anti-leukemia
Chemistry
Chemistry, Applied
Chemistry, Medicinal
cudraisoflavone L
Cudrania tricuspidata
Cytoprotection - drug effects
HL-60 Cells
Humans
Isoflavones - chemistry
Isoflavones - isolation & purification
Isoflavones - pharmacology
Life Sciences & Biomedicine
Macrophages - drug effects
Mice
Molecular Structure
Moraceae - chemistry
Nitric Oxide - biosynthesis
NO inhibitor
Pharmacology & Pharmacy
Physical Sciences
Plant Roots - chemistry
Plant Sciences
Prenylated isoflavone
Prenylation
Science & Technology
Title Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation
URI https://www.tandfonline.com/doi/abs/10.1080/10286020.2016.1232253
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https://www.ncbi.nlm.nih.gov/pubmed/27649772
https://www.proquest.com/docview/1886644492/abstract/
https://search.proquest.com/docview/1859738877
Volume 19
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