Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model

• Published in: The aging male Vol. 23; no. 5; pp. 1009 - 1015
• Main Authors: Da Silva, Marcello H. A., Medeiros, Jorge L., Costa, Waldemar S., Sampaio, Francisco J. B., De Souza, Diogo B.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2020; Taylor & Francis Ltd
• Subjects: 5-alpha Reductase Inhibitors; Aging; Animals; Benign prostatic hyperplasia; Disease Models, Animal; Drug therapy; dutasteride; Dutasteride - therapeutic use; Erectile dysfunction; Humans; Hypertension; Male; Morphology; Penis; Prostatic Hyperplasia - drug therapy; Rats; Rodents; sildenafil; Sildenafil Citrate; Smooth muscle; dutasteride; Benign prostatic hyperplasia; penis; sildenafil; erectile dysfunction
• ISSN: 1368-5538; 1473-0790
• DOI: 10.1080/13685538.2019.1653839

The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model. Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hypertensive rats (SHRs); BPH + D, SHRs treated with dutasteride; and BPH + DS, SHRs treated with dutasteride and sildenafil. All treatments were performed during 40 days, following which the penises were collected for histomorphometrical analysis. The results were compared via one-way ANOVA with Bonferroni's post-test, considering p values <.05 as significant. The smooth muscle density decreased by 28.6% and 21.4% in BPH + D and BPH + DS, respectively, when compared to the BPH group. The sinusoid space density reduced by 32.2% in BPH, when compared to the Ctrl group; this density was also reduced by 22.6% in BPH + D, when compared to the BPH group. The density of the elastic fibers increased 51.6% and 65.6% in BPH + D and BPH + DS, when compared to the BPH group. Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil did not prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers.