New method for reducing viscosity and shear stress in hydrogel 3D printing via multidimension vibration

• Published in: Computer methods in biomechanics and biomedical engineering Vol. 25; no. 16; pp. 1796 - 1811
• Main Authors: Lin, Sheng, Li, Bicong, Yang, Liang, Zhai, Yun, Wang, Xiaoyu, Wang, Chun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 10.12.2022; Taylor & Francis Ltd
• Subjects: Cell survival; Hydrogel 3D printing; Hydrogels; multidimension vibration; Parameters; Printing; Shear stress; Simulation analysis; Survival; Three dimensional printing; Tissue engineering; Vibration; Viscosity; Wall shear stresses; Hydrogel 3D printing; viscosity; shear stress; multidimension vibration
• ISSN: 1025-5842; 1476-8259
• DOI: 10.1080/10255842.2022.2039129

Microextrusion 3D bioprinting is a comparatively easy method to fabricate structures in tissue engineering. But high viscosity and wall shear stress in the tube and nozzle often lead to low cell survival rate of printed tissue. To reduce the viscosity and shear stress of materials in biological 3D printing, a multidimension microvibration assisted hydrogel 3D printing method was proposed. The compliant mechanism driven by piezoceramic was applied to 3D printing of hydrogels. The shear stress and viscosity of hydrogels could be effectively reduced by multidimension microvibration. Simulation analysis of the extrusion device was carried out to study the influence of vibration parameters on viscosity and shear stress, and optimized multidimension vibration forms and vibration parameters were selected for experiments. The experiment results show that multidimension microvibration can effectively reduce the viscosity of hydrogels and improve printing resolution and print speed.