Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: its updated diagnostic criteria, preoperative cytologic diagnoses and impact on the risk of malignancy

Due to the extremely indolent behavior, a subset of noninvasive encapsulated follicular variant papillary thyroid carcinomas has been classified as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)” since 2016 and is no longer considered carcinoma. Since the intro...

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Bibliographic Details
Published inJournal of pathology and translational medicine Vol. 56; no. 6; pp. 319 - 325
Main Author Park, So Yeon
Format Journal Article
LanguageEnglish
Published Seoul Korean Society of Pathologists, Korean Society for Cytopathology 01.11.2022
The Korean Society of Pathologists and the Korean Society for Cytopathology
Korean Society of Pathologists & the Korean Society for Cytopathology
Subjects
Cellular biology
fine-needle aspiration cytology
Jargon
Lymphatic system
Metastasis
Mutation
noninvasive follicular thyroid neoplasm with papillary-like nuclear features
Review
risk of malignancy
thyroid
Thyroid gland
Tumors
Asia
North America
Europe
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Summary:Due to the extremely indolent behavior, a subset of noninvasive encapsulated follicular variant papillary thyroid carcinomas has been classified as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)” since 2016 and is no longer considered carcinoma. Since the introduction of this new terminology, changes and refinements have been made in diagnostic criteria. Initially, the incidence of NIFTP was estimated substantial. However, the reported incidence of NIFTP varies greatly among studies and regions, with higher incidence in North American and European countries than in Asian countries. Thus, the changes in the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) differ inevitably among regions. Because more conservative surgery is recommended for NIFTPs, distinguishing NIFTPs from papillary thyroid carcinomas in preoperative fine-needle aspiration cytology became one of the major concerns. This review will provide comprehensive overview of updates on diagnostic criteria, actual incidence and preoperative cytologic diagnoses of NIFTP, and its impact on the ROM in TBSRTC.
Bibliography:ObjectType-Article-2
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ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2022.09.29