Intra-articular injection of clioquinol ameliorates osteoarthritis in a rabbit model

Osteoarthritis (OA) is characterized by the degeneration of articular cartilage. Decreased autophagy is tightly associated with chondrocyte death, which contributes to the progression of OA. Thus, pharmacological activation of autophagy may be a promising therapeutic approach for OA. Here, we discov...

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Published inFrontiers in medicine Vol. 9; p. 1028575
Main Authors Wu, Xiaoqing, Xu, Peng, Shi, Xuanren, Shang, Jian, Chen, Xiaoyong, Guo, Anyun, Wang, Fuming, Yin, Zhanhai
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 17.11.2022
Subjects
autophagy
clioquinol
intra-articular injection
Medicine
osteoarthritis
therapeutic potential
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Summary:Osteoarthritis (OA) is characterized by the degeneration of articular cartilage. Decreased autophagy is tightly associated with chondrocyte death, which contributes to the progression of OA. Thus, pharmacological activation of autophagy may be a promising therapeutic approach for OA. Here, we discovered that clioquinol, an antibiotic, significantly induces autophagy in OA chondrocytes from human tissue and rabbit model. Meanwhile, clioquinol can also augment the expression of extracellular matrix (ECM) components and suppress inflammatory mediators to improve OA microenvironment. Intra-articular injection of clioquinol can greatly prevent or slow down the development of this disease in a trauma-induced rabbit model of osteoarthritis. Such protective effect induced by clioquinol was at least in part explained by decreasing chondrocyte apoptosis and increasing autophagy. This study reveals the therapeutic potential of clioquinol in OA treatment.
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Edited by: Henrotin Edgard Henrotin, University of Liège, Belgium
This article was submitted to Rheumatology, a section of the journal Frontiers in Medicine
Reviewed by: K. C. Ranjan, Children’s Hospital of Philadelphia, United States; Yong-zhen Zhai, Shengjing Hospital of China Medical University, China
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2022.1028575