Lambda's Switch: Lessons from a Module Swap

A recent experiment has replaced Cro, a crucial component of lambda's genetic switch, with the lac repressor (plus two lac operators). The resulting hybrid phage is viable, but a subtle phenotypic defect explains a puzzle concerning the workings of the switch.

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Bibliographic Details
Published inCurrent biology Vol. 16; no. 12; pp. R459 - R462
Main Author Ptashne, Mark
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 20.06.2006
Subjects
Bacteriophage lambda - genetics
Bacteriophage lambda - physiology
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Evolution, Molecular
Gene Expression Regulation, Viral
Models, Genetic
Operator Regions, Genetic
Repressor Proteins - genetics
Repressor Proteins - metabolism
Viral Proteins - genetics
Viral Proteins - metabolism
Viral Regulatory and Accessory Proteins
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Summary:A recent experiment has replaced Cro, a crucial component of lambda's genetic switch, with the lac repressor (plus two lac operators). The resulting hybrid phage is viable, but a subtle phenotypic defect explains a puzzle concerning the workings of the switch.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2006.05.037