Monascuslactams A-D, cytotoxic γ-lactams from marine fungus Monascus albidus BB3

• Published in: Natural product research Vol. 36; no. 10; pp. 2534 - 2541
• Main Authors: Guo, Qi, Dai, Xiao-Ming, Lan, Wen-Jian, Chen, Liu-Ping, Lam, Chi-Keung, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Li, Hou-Jin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.05.2022; Taylor & Francis Ltd
• Subjects: amino acid-directed strategy; Amino acids; Cytotoxicity; Data analysis; Fungi; L-Serine; Lysine; Marine fungus; Metabolites; Methionine; Monascus; Monascus albidus; monascuslactam; NMR; Nuclear magnetic resonance; Phenylalanine; Threonine; Toxicity; Tryptophan; Tumor cell lines; Valine; γ-lactam; monascuslactam; amino acid-directed strategy; Marine fungus; Monascus albidus; γ-lactam
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2021.1915308

Amino acid-directed strategy becomes an efficient way to explore the alkaloids' biosynthetic potential of marine fungi. The metabolites of marine fungus Monascus albidus BB3 were regulated obviously when cultured in GPY medium supplemented with L-tryptophan, L-phenylalanine, D,L-methionine, L-threonine, L-lysine, L-serine and L-valine. Four new γ-lactams, monascuslactams A-D (1-4), together with two known compounds pulchellalactam (5) and O-acetylperlolyrine (6) were obtained. Their structures were determined by comprehensive analysis on the 1 D and 2 D NMR, HRESIMS, UV and IR data, and their absolute configurations were assigned by the experimental and calculated ECD data analysis. Compounds 3, 4 and 6 showed moderate cytotoxicity against human cancer cell lines SUNE1, HepG2, QGY7701, GLC82, HCT116 and MDA-MB-231.