The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication
In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-α and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-...
Saved in:
Published in | Journal of Huazhong University of Science and Technology. Medical sciences Vol. 27; no. 6; pp. 739 - 741 |
---|---|
Main Author | |
Format | Journal Article |
Language | English |
Published |
China
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan. 430022. China
01.12.2007
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-α and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P〈0.05). Meanwhile, there was a obvious correlation between the increase of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus. |
---|---|
Bibliography: | TNF-α; ICAM-1; lichen planus ICAM-1 42-1679/R TNF-α lichen planus R751 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1672-0733 1993-1352 |
DOI: | 10.1007/s11596-007-0632-x |