The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 27; no. 6; pp. 739 - 741
• Main Author: 陈旭娥 刘志香 岳青 刘厚君 吴艳 李家文
• Format: Journal Article
• Language: English
• Published: China Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan. 430022. China 01.12.2007
• Subjects: Adult; Female; Humans; ICAM-1; Immunohistochemistry; Intercellular Adhesion Molecule-1 - metabolism; Lichen Planus - metabolism; Male; Middle Aged; Skin - metabolism; TNF-α; Tumor Necrosis Factor-alpha - metabolism; 基因表达; 皮肤病; 苔藓病; TNF-α; lichen planus; ICAM-1
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-007-0632-x

In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-α and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins （both P〈0.05）. Meanwhile, there was a obvious correlation between the increase of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus.