State-of-the-Art on Functional Titanium Dioxide-Integrated Nano-Hybrids in Electrical Biosensors

• Published in: Critical reviews in analytical chemistry Vol. 52; no. 3; pp. 637 - 648
• Main Authors: Nadzirah, Sh, Gopinath, Subash C.B, Parmin, N.A., Hamzah, Azrul Azlan, Mohamed, Mohd Ambri, Chang, Edward Yi, Dee, Chang Fu
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2022; Taylor & Francis Ltd
• Subjects: Biosensing Techniques - methods; Biosensors; Commercialization; Construction; Electrochemical biosensor; Electrochemical Techniques - methods; electronic transducer; Hybrids; nanocomposite; Nanomaterials; Nanostructures; Nanotechnology; organic-inorganic materials; Performance enhancement; quantitative biosensor; Reproducibility of Results; Sensitivity enhancement; Titanium; Titanium dioxide; electronic transducer; nanocomposite; organic–inorganic materials; Electrochemical biosensor; quantitative biosensor
• ISSN: 1040-8347; 1547-6510
• DOI: 10.1080/10408347.2020.1816447

Biosensors operating based on electrical methods are being accelerated toward rapid and efficient detection that improve the performance of the device. Continuous study in nano- and material-sciences has led to the inflection with properties of nanomaterials that fit the trend parallel to the biosensor evolution. Advancements in technology that focuses on nano-hybrid are being used to develop biosensors with better detection strategies. In this sense, titanium dioxide (TiO 2 ) nanomaterials have attracted extensive interest in the construction of electrical biosensors. The formation of TiO 2 nano-hybrid as an electrical transducing material has revealed good results with high performance. The modification of the sensing portion with a combination (nano-hybrid form) of nanomaterials has produced excellent sensors in terms of stability, reproducibility, and enhanced sensitivity. This review highlights recent research advancements with functional TiO 2 nano-hybrid materials, and their victorious story in the construction of electrical biosensors are discussed. Future research directions with commercialization of these devices and their extensive utilizations are also discussed.