Essential oil composition and biological activities of Aleppo pine (Pinus halepensis Miller) needles collected from different Tunisian regions

• Published in: International journal of environmental health research Vol. 33; no. 1; pp. 83 - 97
• Main Authors: Dakhlaoui, Sarra, Bourgou, Soumaya, Bachkouel, Sarra, Ben Mansour, Rim, Ben Jemaa, Mariem, Jallouli, Slim, Megdiche-Ksouri, Wided, Hessini, Kamel, Msaada, Kamel
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 2023; Taylor & Francis LLC
• Subjects: anti-diabetic activity; anti-inflammatory activity; Antidiabetics; antioxidant activities; Bioactive compounds; Breast cancer; Caryophyllene; Chemical composition; Cytotoxicity; Doxorubicin; essential oil composition; Essential oils; Glucosidase; Inflammation; Myrcene; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Pine needles; Pinus - chemistry; Pinus halepensis; Scavenging; α-Glucosidase; α-Pinene; antioxidant activities; Pinus halepensis; essential oil composition; anti-diabetic activity; anti-inflammatory activity
• ISSN: 0960-3123; 1369-1619
• DOI: 10.1080/09603123.2021.2005001

The aim of this research was to investigate the variation regarding the chemical composition and biological activities of needles essential oils (EOs) of P. halepensis. Chemical profiles demonstrated a significant (P < 0.05) variability among the different EOs. The main identified compounds were caryophyllene (48.77 ± 2.26), phenyl isovalerate (22.22 ± 2.26), β-myrcene (15.55 ± 5.65) and α-pinene (14.52 ± 2.26). Further, it was shown that EO from Tabouba (Tab) displayed the highest DPPH scavenging (IC 50  = 73.03 mg/mL), anti-inflammatory (IC 50  = 23.29 µg/mL) and α-glucosidase inhibition activities (IC 50  = 254.45 µg/mL). While Elmahres (Elm) exhibited the most potent ABTS radical's inhibition (IC 50  = 197.87 mg/mL). For the cytotoxic capacities, Kettana (Ket) was the most efficient against breast cancer MCF-7 cell line with IC 50 value better than doxorubicin used as positive control. Obtained results suggest that EO of P. halepensis could be used as a source of bioactive compounds.