Low-dose estradiol and endothelial and inflammatory biomarkers in menopausal overweight/obese women
Objective: We aimed to investigate the effects of low-dose transdermal estrogen on endothelial and inflammatory biomarkers in menopausal overweight/obese women. Methods: We recruited 44 menopausal women (47-55 years; body mass index 27.5-34.9 kg/m 2 ) and divided them into estradiol (1 mg/day; n = 2...
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Published in | Climacteric : the journal of the International Menopause Society Vol. 19; no. 4; pp. 337 - 343 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis
03.07.2016
Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: We aimed to investigate the effects of low-dose transdermal estrogen on endothelial and inflammatory biomarkers in menopausal overweight/obese women.
Methods: We recruited 44 menopausal women (47-55 years; body mass index 27.5-34.9 kg/m
2
) and divided them into estradiol (1 mg/day; n = 22) or placebo groups (n = 22). They were double-blinded, followed and treated for 3 months. At baseline and post-intervention, inflammatory biomarkers (hs-CRP, IL-1β, IL-6, MCP-1 and TNF-α) and of vascular injury (activated circulating endothelial cells, CEC-a) and repair (endothelial progenitor cells, EPC) were quantified. Resting CECs (CEC-r) were also assessed. Microvascular reactivity and vasomotion were analyzed by laser-Doppler flowmetry.
Results: Volunteers (51.8 ± 2.3 years; mean body mass index 31.5 ± 2.5 kg/m
2
) had been menopausal for 3 (range 2-5) years. After treatment, no changes were observed in the placebo group, while levels of CEC-r and EPC increased in the estradiol group. In this group, no changes in inflammatory biomarkers were observed but it required a lower cumulative dose of acetylcholine to achieve peak velocity during endothelial-dependent vasodilatation and there was increased endothelial-independent vasodilatation.
Conclusions: The short-term use of low-dose transdermal estradiol therapy in overweight/obese menopausal women increased markers of vascular repair and improved microvascular reactivity without changing the inflammatory biomarkers.
Clinical trial registration: NCT01295892 at
www.clinicaltrials.gov
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 1369-7137 1473-0804 |
DOI: | 10.1080/13697137.2016.1180676 |