Signaling Interplay in Ras Superfamily Function

Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiated by extracellular stimuli. Activated Ras in turn regulates a diversity of downstream cytoplasmic signaling cascades. Ras proteins are founding members of a large superfamily of small GTPases that hav...

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Bibliographic Details
Published inCurrent biology Vol. 15; no. 14; pp. R563 - R574
Main Authors Mitin, Natalia, Rossman, Kent L., Der, Channing J.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 26.07.2005
Subjects
Cytoplasm - metabolism
Gene Components
GTPase-Activating Proteins - metabolism
Guanine Nucleotide Exchange Factors - metabolism
Humans
Models, Biological
ras Proteins - metabolism
ras Proteins - physiology
Second Messenger Systems - physiology
Signal Transduction - physiology
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Summary:Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiated by extracellular stimuli. Activated Ras in turn regulates a diversity of downstream cytoplasmic signaling cascades. Ras proteins are founding members of a large superfamily of small GTPases that have significant sequence and biochemical similarities. Recent observations have established a complex signaling interplay between Ras and other members of the family. A key biochemical mechanism facilitating this crosstalk involves guanine nucleotide exchange factors (GEFs), which serve as regulators and effectors, as well as signaling integrators, of Ras signaling.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2005.07.010