Electrochemical Sensors for the Detection of Reactive Oxygen Species in Biological Systems: A Critical Review

Reactive oxygen species (ROS) involving superoxide anion, hydrogen peroxide and hydroxyl radical play important role in human health. ROS are known to be the markers of oxidative stress associated with different pathologies including neurodegenerative and cardiovascular diseases, as well as cancer....

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Published inCritical reviews in analytical chemistry Vol. 54; no. 4; pp. 742 - 774
Main Authors Geraskevich, Alina V., Solomonenko, Anna N., Dorozhko, Elena V., Korotkova, Elena I., Barek, Jiří
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 18.05.2024
Taylor & Francis Ltd
Subjects
Animals
Biological objects
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
body fluid
Body fluids
Cardiovascular diseases
cell
Chemical sensors
electrochemical sensor
Electrochemical Techniques - instrumentation
Electrochemistry
Humans
Hydrogen peroxide
Hydroxyl radicals
Oxidative Stress
Oxygen
Reactive oxygen species
Reactive Oxygen Species - analysis
Reactive Oxygen Species - metabolism
Sensors
Superoxide anions
body fluid
Biological objects
electrochemical sensor
cell
reactive oxygen species
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Summary:Reactive oxygen species (ROS) involving superoxide anion, hydrogen peroxide and hydroxyl radical play important role in human health. ROS are known to be the markers of oxidative stress associated with different pathologies including neurodegenerative and cardiovascular diseases, as well as cancer. Accordingly, ROS level detection in biological systems is an essential problem for biomedical and analytical research. Electrochemical methods seem to have promising prospects in ROS determination due to their high sensitivity, rapidity, and simple equipment. This review demonstrates application of modern electrochemical sensors for ROS detection in biological objects (e.g., cell lines and body fluids) over a decade between 2011 and 2021. Particular attention is paid to sensors materials and various types of modifiers for ROS selective detection. Moreover, the sensors comparative characteristics, their main advantages, disadvantages and their possibilities and limitations are discussed.
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ISSN:1040-8347
1547-6510
1547-6510
DOI:10.1080/10408347.2022.2098669