Two new secolignans from the roots of Urtica fissa

Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spe...

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Bibliographic Details
Published inJournal of asian natural products research Vol. 21; no. 2; pp. 165 - 170
Main Authors Lu, Xuan, Li, Xue-Qing, Qin, Hai-Hong, Feng, Bao-Min, Cheng, Xing-Hua, Yang, Qing-Xiong, Yu, Da-Yong, Shi, Li-Ying, Yu, Zong-Xia, Fang, Xue-Xun
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 01.02.2019
Taylor & Francis Ltd
Subjects
Butyrolactone
Chemistry
Chemistry, Applied
Chemistry, Medicinal
Life Sciences & Biomedicine
neuraminidases
NMR
Nuclear magnetic resonance
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Roots
Science & Technology
Secolignans
structual analysis
Urtica fissa
NEURAMINIDASE
GLYCOSIDES
Secolignans
structual analysis
neuraminidases
VIRUS
Urtica fissa
AGENTS
EXTRACTS
DIOICA
INHIBIT
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Summary:Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spectroscopic methods, especially 1 H NMR, 13 C NMR, 2D NMR, and HR-ESI-MS. The inhibitory effects on N1 and N2, two subtypes of neuraminidases (NAs), of these two compounds were assayed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2017.1411347