Reactive oxygen species in cancer cells: Live by the sword, die by the sword

Reactive oxygen species and tumor biology are intertwined in a complex web, making it difficult to understand which came first, whether oxidants are required for tumor cell growth, and whether oxidant stress can be exploited therapeutically. Evidence suggests that transformed cells use ROS signals t...

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Bibliographic Details
Published inCancer cell Vol. 10; no. 3; pp. 175 - 176
Main Author Schumacker, Paul T.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2006
Subjects
Antineoplastic Agents - therapeutic use
Apoptosis - drug effects
Neoplasms - complications
Neoplasms - drug therapy
Neoplasms - metabolism
Reactive Oxygen Species - metabolism
Thioredoxins - metabolism
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Summary:Reactive oxygen species and tumor biology are intertwined in a complex web, making it difficult to understand which came first, whether oxidants are required for tumor cell growth, and whether oxidant stress can be exploited therapeutically. Evidence suggests that transformed cells use ROS signals to drive proliferation and other events required for tumor progression. This confers a state of increased basal oxidative stress, making them vulnerable to chemotherapeutic agents that further augment ROS generation or that weaken antioxidant defenses of the cell. In this respect, it appears that tumor cells may die by the same systems they require.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2006.08.015