Sustained-Release Implants of Chemical Carcinogens in the Canine Tracheobronchial Tree

• Published in: The Annals of thoracic surgery Vol. 25; no. 2; pp. 112 - 116
• Main Authors: Matsumura, Kimito, Shors, Edwin C., Fu, Paul C., Cohen, Arthur H., Benfield, John R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.1978
• Subjects: Animals; Benzopyrenes - administration & dosage; Bronchi - drug effects; Bronchi - pathology; Bronchi - surgery; Carcinogens - administration & dosage; Cricetinae; Delayed-Action Preparations; Dogs; Drug Implants; Metaplasia - chemically induced; Neoplasms, Experimental - chemically induced; Polymers; Silicone Elastomers; Trachea - drug effects; Trachea - pathology; Trachea - surgery
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/S0003-4975(10)63501-1

A proved carcinogen, benzo[ a]pyrene (BP), was incorporated into liquid silicone rubber polymer which was then vulcanized into solid form. Discs of BP polymer containing 9.05 to 12.12% BP were sutured into the trachea and right main bronchi of 10 dogs which were observed for 3 to 8 months. The discs were either in contact with the endobronchial surface of the mucosa or placed into submucosal pockets. All discs that were implanted submucosally remain in place. Only 2 discs implanted by the fixation method were extruded. The pocket implants of BP polymer caused ulceration and erosion of the mucosa; these changes did not occur from discs of polymer without carcinogen. To date these implants have induced squamous metaplasia with atypical changes. A method for sustained-release implantation of carcinogens in the canine tracheobronchial tree has been developed.