Selective sample treatment using molecularly imprinted polymers

• Published in: Journal of Chromatography A Vol. 1152; no. 1; pp. 41 - 53
• Main Author: Pichon, Valérie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 08.06.2007; Elsevier
• Subjects: Analytical chemistry; Benzhydryl Compounds; Chemical Sciences; Cholesterol - isolation & purification; Chromatography, Gas; Chromatography, Liquid - methods; Complex matrices; Molecularly imprinted polymers; Phenols - isolation & purification; Polymers - chemical synthesis; Polymers - chemistry; Quinazolines - isolation & purification; Selectivity; Solid Phase Extraction - methods; Solid-phase extraction; Molecularly imprinted polymers; Selectivity; Complex matrices; Solid-phase extraction
• ISSN: 0021-9673; 1873-3778
• DOI: 10.1016/j.chroma.2007.02.109

The molecularly imprinted polymers (MIPs) are synthetic polymers possessing specific cavities designed for a target molecule. By a mechanism of molecular recognition, the MIPs are used as selective sorbents for the solid-phase extraction of target analytes from complex matrices. MIPs are often called synthetic antibodies in comparison with immuno-based sorbents; they offer some advantages including easy, cheap and rapid preparation and high thermal and chemical stability. This review describes the use of MIPs in solid-phase extraction with emphasis on their synthesis, the various parameters affecting the selectivity of the extraction, their potential to selectively extract analytes from complex aqueous samples or organic extracts, their on-line coupling with LC and their potential in miniaturized devices.