Noble Metals Based Bimetallic and Trimetallic Nanoparticles: Controlled Synthesis, Antimicrobial and Anticancer Applications

• Published in: Critical reviews in analytical chemistry Vol. 51; no. 5; pp. 454 - 481
• Main Authors: Ali, Shujat, Sharma, Arumugam Selva, Ahmad, Waqas, Zareef, Muhammad, Hassan, Md Mehdi, Viswadevarayalu, Annavaram, Jiao, Tianhui, Li, Huanhuan, Chen, Quansheng
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2021; Taylor & Francis Ltd
• Subjects: Anticancer and antimicrobial; Antiinfectives and antibacterials; Antimicrobial agents; bimetallic and trimetallic; Bimetals; Biocompatibility; Biomedical materials; Cancer; Chemical reduction; chemical reduction method; Chemical synthesis; Composition; controlled shape and size; Cytotoxicity; Literature reviews; Metals; Morphology; Nanomaterials; Nanoparticles; Nanotechnology; Noble metals; noble metals nanoparticles; Parameters; Reducing agents; Reviews; Surface structure; Synergism; Toxicity; bimetallic and trimetallic; Anticancer and antimicrobial; noble metals nanoparticles; chemical reduction method; controlled shape and size
• ISSN: 1040-8347; 1547-6510
• DOI: 10.1080/10408347.2020.1743964

Noble bimetallic and trimetallic nanoparticles (NBT-NPs) have superior biomedical applications as compared to their monometallic counterparts. The performance of these nanomaterials depends on their composition, shape and size. Hence, the controlled-synthesis of these nanomaterials is a hot area of research. Till date, no review article in the literature accounts regarding the controlled-synthesis and biomedical applications related to morphology, optimum composition, biocompatibility and versatile chemistry of NBT-NPs. Taking this into contemplation, an effort was made to provide a clear insight into the morphology-controlled synthesis and size/shape-dependent anticancer and bactericidal applications of NBT-NPs. Chemical reduction method for the controlled-synthesis of NBT-NPs is reviewed critically. Furthermore, the potential role of various reaction parameters such as time, reducing agents, stabilizing/capping agents, nature/concentration of precursors, temperature and pH in the shape/size-controlled synthesis of these nanomaterials are discussed. In the second part of this article, anticancer and bactericidal applications of the NBT-NPs are reviewed and the influences of optimum composition, size, surface structure, versatile chemistry and synergism are studied. Finally, the current challenges in the controlled-synthesis and biomedical applications of these nanomaterials, and prospects to resolve related issues are discussed. Highlights Chemical reduction method for the synthesis of NBT-NPs is reviewed. The influences of parameters on the control synthesis of NBT-NPs are discussed. Antibacterial and anticancer applications and cytotoxicity of NBT-NPs are reviewed. Possible solutions for the key challenges are discussed. Outlooks about the synthesis and biomedical applications of NBT-NPs are discussed.