Armochaetoglasins J and K: new cytochalasans from Chaetomium globosum

Two novel cytochalasans, armochaetoglasin J (1) and armochaetoglasin K (2), along with 14 known analogues (3−16) were isolated from Chaetomium globosum. Their structures were elucidated by HRESIMS, NMR spectroscopy, single-crystal X-ray crystallography, and ECD spectra. Armochaetoglasins J and K wer...

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Published inNatural product research Vol. 36; no. 14; pp. 3603 - 3609
Main Authors Cheng, Li, Zheng, Xi, Li, Qin, Wei, Meng-Sha, Chen, Chun-Mei, Zhu, Hu-Cheng, Zeng, Chang-Li, Hao, Xin-Cai, Zhang, Yong-Hui
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 15.07.2022
Taylor & Francis Ltd
Subjects
Chaetomium globosum
Crystal structure
Crystallography
cytochalasan
Magnetic resonance spectroscopy
NMR
NMR spectroscopy
Nuclear magnetic resonance
secondary metabolites
Single crystals
Tumor cell lines
X-ray crystallography
Chaetomium globosum
cytochalasan
secondary metabolites
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Summary:Two novel cytochalasans, armochaetoglasin J (1) and armochaetoglasin K (2), along with 14 known analogues (3−16) were isolated from Chaetomium globosum. Their structures were elucidated by HRESIMS, NMR spectroscopy, single-crystal X-ray crystallography, and ECD spectra. Armochaetoglasins J and K were found to be inactive against the HepG2, HT-29, K562, HL-60, and A549 cancer cell lines.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1872568