Antioxidative 2-(2-phenylethyl)chromones in Chinese eaglewood from Aquilaria sinensis

• Published in: Journal of asian natural products research Vol. 22; no. 7; pp. 639 - 646
• Main Authors: Li, Chun-Ge, Pan, Li, Han, Zhu-Zhen, Xie, Yan-Qiao, Hu, Hai-Jun, Liu, Xiao-Long, Wu, Li-Hong, Yang, Li, Wang, Zheng-Tao
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 02.07.2020; Taylor & Francis Ltd
• Subjects: 2-(2-phenylethyl)chromones; Absolute configuration; ABTS; antioxidant activity; Aquilaria sinensis; Chemistry; Chemistry, Applied; Chemistry, Medicinal; Chinese eaglewood; Chromones; Crystallography; Flavonoids; Life Sciences & Biomedicine; Molecular Structure; NMR; Nuclear magnetic resonance; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; radical scavenging activity; Resins; Scavenging; Science & Technology; Thymelaeaceae; CHROMONE; ABTS(center dot+) radical scavenging activity; 2-(2-phenylethyl)chromones; Aquilaria sinensis; AGARWOOD; antioxidant activity; DERIVATIVES; Chinese eaglewood; ABTS•+ radical scavenging activity
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2019.1607841

Two new compounds 6,7-dimethoxy-2-[2-(2′-hydroxyphenyl)ethyl]chromone (1) and 6,7-dimethoxy-2-[2-(4′-hydroxyphenyl)ethenyl]chromone (2), together with ten known 2-(2-phenylethyl)chromones (3-12) were isolated from the resinous wood of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by detailed IR, MS, NMR spectroscopic analyses, and comparison with reported. The absolute configuration of 3 was confirmed by Cu Kα X-ray crystallographic experiment, and the X-ray crystallographic data of 3 were firstly reported. Compounds 2, 8, 10, and 11 exhibited strong ABTS *+ radical scavenging activity, with IC 50 values of 12.3, 16.5, 12.1, and 34.7 μM, respectively.