Dysport ®: Pharmacological properties and factors that influence toxin action
The pharmacological properties of Dysport ® that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data....
Saved in:
| Published in | Toxicon (Oxford) Vol. 54; no. 5; pp. 683 - 689 |
|---|---|
| Main Author | |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
01.10.2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The pharmacological properties of Dysport
® that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered. |
|---|---|
| AbstractList | The pharmacological properties of Dysport that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered.The pharmacological properties of Dysport that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered. The pharmacological properties of Dysport ® that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered. The pharmacological properties of Dysport that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered. |
| Author | Pickett, Andy |
| Author_xml | – sequence: 1 givenname: Andy surname: Pickett fullname: Pickett, Andy email: andy.pickett@ipsen.com organization: Biologicals Science and Technology, Ipsen Biopharm Limited, Wrexham, UK |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22063565$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19332087$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1uFDEUhC0URCaBI4C8Qay6ebbb_QMLhJIAkSJgAWvL7X4mHvXYg-1B5FIcIieLWzNkkU1WXvirUr2qE3Lkg0dCXjKoGbD27brO4a8zwdccYKhB1MDhCVmxvhsqwSQckRVAwyoo-DE5SWkNAKIf2mfkmA1CcOi7Ffl6fpO2IWZ6--8d_X6t40abMIdfzuiZbmPYYswOE9V-olabHGKi-Vpn6rydd-gN0iWHp-XPBf-cPLV6Tvji8J6Sn58ufpx9qa6-fb48-3hVGTE0uWptg8CxlyiAda0YRya6DhkfubCika02kve8k8yMrRWjaHiPUnM7cbQ9Z-KUvNn7loi_d5iy2rhkcJ61x7BLqhNNKak4FPLVgdyNG5zUNrqNjjfqfwUFeH0AdCpH26i9ceme4xxaIVtZuPd7zsSQUkSrjMt6OTpH7WbFQC3DqLU6DKOWYRQIVYYpavlAfR_kEd2HvQ5Lm38cRpWMW2qfXEST1RTcIw53ARmq3Q |
| CODEN | TOXIA6 |
| CitedBy_id | crossref_primary_10_1097_PSN_0000000000000292 crossref_primary_10_1007_s40261_018_0701_x crossref_primary_10_3109_14764172_2010_514918 crossref_primary_10_1155_2013_686329 crossref_primary_10_1177_1090820X12455192 crossref_primary_10_1097_PSN_0000000000000091 crossref_primary_10_3109_00207454_2010_539306 crossref_primary_10_1016_j_jaad_2011_08_011 crossref_primary_10_1111_j_1473_2165_2011_00574_x crossref_primary_10_1093_asj_sjw285 crossref_primary_10_1093_asj_sjx010 crossref_primary_10_1002_phar_1196 crossref_primary_10_1080_14712598_2018_1510486 crossref_primary_10_1002_mds_25582 crossref_primary_10_1016_j_cps_2016_03_001 crossref_primary_10_1016_S0028_3843_14_60406_0 crossref_primary_10_1016_j_jaad_2023_12_026 crossref_primary_10_4155_cli_14_74 crossref_primary_10_1111_ene_12517 crossref_primary_10_1001_archfaci_2011_1142 crossref_primary_10_1111_jocd_13702 crossref_primary_10_2174_0113816128284720240212111926 crossref_primary_10_1016_j_parkreldis_2011_06_016 crossref_primary_10_1111_j_1468_3083_2009_03475_x crossref_primary_10_1038_nrneurol_2010_149 crossref_primary_10_1586_ern_09_121 crossref_primary_10_1016_j_neuroscience_2011_01_033 crossref_primary_10_3390_toxins8030065 crossref_primary_10_4103_jrms_jrms_372_21 crossref_primary_10_1097_DSS_0000000000001412 crossref_primary_10_17116_plast_hirurgia202002167 crossref_primary_10_1097_DSS_0000000000001277 crossref_primary_10_1111_j_1468_1331_2010_03056_x crossref_primary_10_1007_s40265_018_1042_z crossref_primary_10_1016_j_cps_2011_03_010 crossref_primary_10_2165_11590750_000000000_00000 |
| Cites_doi | 10.1016/S0003-9861(53)80014-7 10.1016/j.toxicon.2008.04.030 10.1128/MMBR.56.1.80-99.1992 10.1016/0163-7258(82)90061-4 10.1504/TBJ.2008.018956 10.1504/TBJ.2008.018951 10.1111/j.1745-4565.1977.tb00259.x 10.1111/j.1473-2165.2008.00361.x 10.1111/j.1468-1331.2006.01649.x 10.1080/17429590701523794 10.1021/bi0355544 10.1016/S0041-0101(03)00196-X 10.1002/andp.18551700105 10.1001/archderm.143.11.1447-b 10.1111/j.1365-2710.2008.00904.x 10.1111/j.1468-1331.2006.01438.x 10.1111/j.1524-4725.2006.32330.x 10.1111/j.1524-4725.2007.34008.x 10.1016/S0140-6736(94)91806-6 |
| ContentType | Journal Article Conference Proceeding |
| Copyright | 2009 Elsevier Ltd 2009 INIST-CNRS |
| Copyright_xml | – notice: 2009 Elsevier Ltd – notice: 2009 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.toxicon.2009.03.020 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1879-3150 |
| EndPage | 689 |
| ExternalDocumentID | 19332087 22063565 10_1016_j_toxicon_2009_03_020 S0041010109001810 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFNM ABFRF ABFYP ABGSF ABJNI ABLST ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC C45 CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSU SSZ T5K TEORI TWZ WUQ XOL Y6R ZGI ZXP ~02 ~G- ~KM AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH EFKBS IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c394t-6f4e02e85e301763bb1377e12b23f3456ac5282751cb6f3b3428e5a2fd2ef8213 |
| IEDL.DBID | AIKHN |
| ISSN | 0041-0101 1879-3150 |
| IngestDate | Mon Jul 21 11:32:57 EDT 2025 Mon Jul 21 05:59:03 EDT 2025 Mon Jul 21 09:14:03 EDT 2025 Thu Apr 24 23:02:26 EDT 2025 Tue Jul 01 01:46:01 EDT 2025 Fri Feb 23 02:32:02 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Botulinum toxin complex Complex size Spread Dysport Diffusion of toxin Dissociation Botulinum toxin Botulinum toxin Type A Enzyme Metalloendopeptidases Biological activity Peptidases Toxin Bontoxilysin Hydrolases Diffusion |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MeetingName | Toxins 2008: Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins |
| MergedId | FETCHMERGED-LOGICAL-c394t-6f4e02e85e301763bb1377e12b23f3456ac5282751cb6f3b3428e5a2fd2ef8213 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 19332087 |
| PQID | 734016827 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_734016827 pubmed_primary_19332087 pascalfrancis_primary_22063565 crossref_citationtrail_10_1016_j_toxicon_2009_03_020 crossref_primary_10_1016_j_toxicon_2009_03_020 elsevier_sciencedirect_doi_10_1016_j_toxicon_2009_03_020 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-10-01 |
| PublicationDateYYYYMMDD | 2009-10-01 |
| PublicationDate_xml | – month: 10 year: 2009 text: 2009-10-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Kidlington |
| PublicationPlace_xml | – name: Kidlington – name: England |
| PublicationTitle | Toxicon (Oxford) |
| PublicationTitleAlternate | Toxicon |
| PublicationYear | 2009 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Aoki, Peng, Gruber, Spanoyannis (bib1) 1995; 2 Scott, Rosenbaum, Collins (bib23) 1973; 12 Rosales, Bigalke, Dressler (bib20) 2006; 13 Cliff (bib3) 2007; 20 Eisele, K.-H., Taylor, H.V., 2008. Dissociation of the 900 Sugii, Sakaguchi (bib22) 1977; 1 Pickett, Caird (bib18) 2008; 33 Poulain, Popoff, Molgo (bib19) 2008; 1 Sharma, Singh (bib25) 2004; 43 kDa neurotoxin complex from Hexsel, Dal'Forno, Hexsel, Zechmeister do Prado, Lima (bib12) 2007; 34 Cliff, Judodihardjo, Eltringham (bib4) 2008; 7 Matsumura, Jin, Kabumoto, Takegahara, Oguma, Lencer, Fujinaga (bib14) 2008; 10 Wagman, Bateman (bib27) 1953; 45 Pickett, A., Shipley, S., Panjwani, N., O'Keeffe, R., Singh, B.R., 2004. Characterisation and consistency of botulinum toxin type A-haemagglutinin complex used for clinical therapy. In: Poster Presented at the 41st Annual Meeting of the Interagency Botulinum Research Co-ordinating Committee, 27–29 October 2004, Baltimore. Friday, Bigalke, Frevert (bib9) 2002; 365 Schantz, Johnson (bib24) 1992; 56 Pickett, Hambleton (bib16) 1994; 344 de Almeida, De Boulle (bib5) 2007; 9 Hambleton, Pickett (bib10) 1994; 87 Tang-Liu, Aoki, Dolly, de Paiva, Houchen, Chasseaud, Webber (bib26) 2003; 42 Fick (bib8) 1855; 170 de Almeida, Marques, de Almeida, Cunha, Boraso (bib6) 2007; 33 Karsai, Adrian, Hammes, Thimm, Raulin (bib13) 2007; 143 Sakaguchi (bib21) 1983; 19 Aoki, Ranoux, Wissel (bib2) 2006; 13 under physiological conditions. In: Poster Presented at Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, Baveno, Italy, June 12–15, 2008 (P164 published as abstract in Toxicon 51(Suppl. 1), 10). Hambleton, Pickett, Shone (bib11) 2007 Panjwani, O'Keeffe, Pickett (bib15) 2008; 1 Rosales (10.1016/j.toxicon.2009.03.020_bib20) 2006; 13 Friday (10.1016/j.toxicon.2009.03.020_bib9) 2002; 365 Pickett (10.1016/j.toxicon.2009.03.020_bib16) 1994; 344 Schantz (10.1016/j.toxicon.2009.03.020_bib24) 1992; 56 Pickett (10.1016/j.toxicon.2009.03.020_bib18) 2008; 33 Cliff (10.1016/j.toxicon.2009.03.020_bib4) 2008; 7 Hambleton (10.1016/j.toxicon.2009.03.020_bib11) 2007 Hambleton (10.1016/j.toxicon.2009.03.020_bib10) 1994; 87 Matsumura (10.1016/j.toxicon.2009.03.020_bib14) 2008; 10 10.1016/j.toxicon.2009.03.020_bib17 Aoki (10.1016/j.toxicon.2009.03.020_bib1) 1995; 2 Karsai (10.1016/j.toxicon.2009.03.020_bib13) 2007; 143 Panjwani (10.1016/j.toxicon.2009.03.020_bib15) 2008; 1 10.1016/j.toxicon.2009.03.020_bib7 Sakaguchi (10.1016/j.toxicon.2009.03.020_bib21) 1983; 19 Sugii (10.1016/j.toxicon.2009.03.020_bib22) 1977; 1 Sharma (10.1016/j.toxicon.2009.03.020_bib25) 2004; 43 Tang-Liu (10.1016/j.toxicon.2009.03.020_bib26) 2003; 42 Wagman (10.1016/j.toxicon.2009.03.020_bib27) 1953; 45 Cliff (10.1016/j.toxicon.2009.03.020_bib3) 2007; 20 de Almeida (10.1016/j.toxicon.2009.03.020_bib5) 2007; 9 de Almeida (10.1016/j.toxicon.2009.03.020_bib6) 2007; 33 Poulain (10.1016/j.toxicon.2009.03.020_bib19) 2008; 1 Fick (10.1016/j.toxicon.2009.03.020_bib8) 1855; 170 Scott (10.1016/j.toxicon.2009.03.020_bib23) 1973; 12 Aoki (10.1016/j.toxicon.2009.03.020_bib2) 2006; 13 Hexsel (10.1016/j.toxicon.2009.03.020_bib12) 2007; 34 |
| References_xml | – volume: 1 start-page: 53 year: 1977 end-page: 65 ident: bib22 article-title: Botulogenic properties of vegetables with special reference to the molecular size of the toxin in them publication-title: J. Food Safety – volume: 19 start-page: 165 year: 1983 end-page: 194 ident: bib21 publication-title: Pharmacol. Ther. – volume: 13 start-page: 2 year: 2006 end-page: 10 ident: bib20 article-title: Pharmacology of botulinum toxin: differences between type A preparations publication-title: Eur. J. Neurol. – reference: Pickett, A., Shipley, S., Panjwani, N., O'Keeffe, R., Singh, B.R., 2004. Characterisation and consistency of botulinum toxin type A-haemagglutinin complex used for clinical therapy. In: Poster Presented at the 41st Annual Meeting of the Interagency Botulinum Research Co-ordinating Committee, 27–29 October 2004, Baltimore. – volume: 170 start-page: 59 year: 1855 end-page: 86 ident: bib8 article-title: Ueber diffusion publication-title: Ann. Phys. – reference: Eisele, K.-H., Taylor, H.V., 2008. Dissociation of the 900 – volume: 34 start-page: 1 year: 2007 end-page: 8 ident: bib12 article-title: A randomized pilot study comparing the action halos of two commercial preparations of botulinum toxin Type A publication-title: Dermatol. Surg. – volume: 365 start-page: R20 year: 2002 ident: bib9 publication-title: Naunyn-Schmeideberg'S Arch. Pharmacol. – volume: 56 start-page: 80 year: 1992 end-page: 99 ident: bib24 article-title: Properties and use of botulinum toxin and other microbial neurotoxins in medicine publication-title: Microbiol. Rev. – volume: 33 start-page: 327 year: 2008 end-page: 328 ident: bib18 article-title: Comparison of type A botulinum toxin products in clinical use publication-title: J. Clin. Pharm. Ther. – reference: kDa neurotoxin complex from – volume: 10 start-page: 355 year: 2008 end-page: 364 ident: bib14 article-title: The HA proteins of botulinum toxin disrupt intestinal epithelial intracellular junctions to increase toxin adsorption publication-title: Cell. Microbiol. – volume: 1 start-page: 153 year: 2008 end-page: 166 ident: bib15 article-title: Biochemical, functional and potency characteristics of type A botulinum toxin in clinical use publication-title: The Botulinum J. – volume: 344 start-page: 474 year: 1994 ident: bib16 article-title: Dose standardization of botulinum toxin publication-title: Lancet – volume: 1 start-page: 14 year: 2008 end-page: 87 ident: bib19 article-title: How do the botulinum neurotoxins block neurotransmitter release: from botulism to the molecular mechanism of action publication-title: The Botulinum J. – volume: 42 start-page: 461 year: 2003 end-page: 469 ident: bib26 article-title: Intramuscular injection of publication-title: Toxicon – volume: 33 start-page: S37 year: 2007 end-page: S43 ident: bib6 article-title: Pilot study comparing the diffusion of two formulations of botulinum toxin type A inpatients with forehead hyperhidrosis publication-title: Dermatol. Surg. – volume: 43 start-page: 4791 year: 2004 end-page: 4798 ident: bib25 article-title: Enhancement of the endopeptidase activity of purified botulinum neurotoxins A and E by an isolated component of the native neurotoxin associated proteins publication-title: Biochemistry – volume: 2 start-page: 3 year: 1995 end-page: 9 ident: bib1 article-title: Pharmacology of BOTOX publication-title: Eur. J. Neurol. – volume: 13 start-page: 10 year: 2006 end-page: 19 ident: bib2 article-title: Using translational medicine to understand clinical differences between botulinum toxin formulations publication-title: Eur. J. Neurol. – volume: 143 start-page: 1447 year: 2007 end-page: 1449 ident: bib13 article-title: A randomized, double-blind study of the effect of Botox and Dysport/Reloxin on forehead wrinkles and electromyographic activity publication-title: Arch. Dermatol. – volume: 45 start-page: 375 year: 1953 end-page: 383 ident: bib27 article-title: Botulinum type A toxin: properties of a toxic dissociation product publication-title: Arch. Biochem. Biophys. – volume: 9 start-page: 17 year: 2007 end-page: 22 ident: bib5 article-title: Diffusion characteristics of botulinum neurotoxin products and their clinical significance in cosmetic applications publication-title: J. Cosmet. Laser Ther. – volume: 87 start-page: 719 year: 1994 ident: bib10 article-title: Potency equivalence of botulinum toxin preparations publication-title: J. R. Soc. Med. – volume: 12 start-page: 924 year: 1973 end-page: 927 ident: bib23 article-title: Pharmacologic weakening of extraocular muscles publication-title: Invest. Ophthalmol. – volume: 7 start-page: 50 year: 2008 end-page: 54 ident: bib4 article-title: Different formulations of botulinum toxin type A have different migration characteristics: a double-blind, randomized study publication-title: J. Cosmet. Dermatol. – year: 2007 ident: bib11 article-title: Botulinum toxin: from menace to medicine publication-title: Clinical Uses of Botulinum Toxins – reference: under physiological conditions. In: Poster Presented at Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, Baveno, Italy, June 12–15, 2008 (P164 published as abstract in Toxicon 51(Suppl. 1), 10). – volume: 20 start-page: 32 year: 2007 end-page: 35 ident: bib3 article-title: Migration characteristics of botulinum neurotoxins publication-title: Cosmet. Dermatol. – ident: 10.1016/j.toxicon.2009.03.020_bib17 – volume: 45 start-page: 375 year: 1953 ident: 10.1016/j.toxicon.2009.03.020_bib27 article-title: Botulinum type A toxin: properties of a toxic dissociation product publication-title: Arch. Biochem. Biophys. doi: 10.1016/S0003-9861(53)80014-7 – volume: 87 start-page: 719 year: 1994 ident: 10.1016/j.toxicon.2009.03.020_bib10 article-title: Potency equivalence of botulinum toxin preparations publication-title: J. R. Soc. Med. – volume: 10 start-page: 355 year: 2008 ident: 10.1016/j.toxicon.2009.03.020_bib14 article-title: The HA proteins of botulinum toxin disrupt intestinal epithelial intracellular junctions to increase toxin adsorption publication-title: Cell. Microbiol. – ident: 10.1016/j.toxicon.2009.03.020_bib7 doi: 10.1016/j.toxicon.2008.04.030 – volume: 12 start-page: 924 year: 1973 ident: 10.1016/j.toxicon.2009.03.020_bib23 article-title: Pharmacologic weakening of extraocular muscles publication-title: Invest. Ophthalmol. – volume: 56 start-page: 80 issue: 1 year: 1992 ident: 10.1016/j.toxicon.2009.03.020_bib24 article-title: Properties and use of botulinum toxin and other microbial neurotoxins in medicine publication-title: Microbiol. Rev. doi: 10.1128/MMBR.56.1.80-99.1992 – volume: 19 start-page: 165 year: 1983 ident: 10.1016/j.toxicon.2009.03.020_bib21 article-title: Clostridium botulinum toxins publication-title: Pharmacol. Ther. doi: 10.1016/0163-7258(82)90061-4 – volume: 1 start-page: 153 year: 2008 ident: 10.1016/j.toxicon.2009.03.020_bib15 article-title: Biochemical, functional and potency characteristics of type A botulinum toxin in clinical use publication-title: The Botulinum J. doi: 10.1504/TBJ.2008.018956 – volume: 1 start-page: 14 issue: 1 year: 2008 ident: 10.1016/j.toxicon.2009.03.020_bib19 article-title: How do the botulinum neurotoxins block neurotransmitter release: from botulism to the molecular mechanism of action publication-title: The Botulinum J. doi: 10.1504/TBJ.2008.018951 – volume: 1 start-page: 53 year: 1977 ident: 10.1016/j.toxicon.2009.03.020_bib22 article-title: Botulogenic properties of vegetables with special reference to the molecular size of the toxin in them publication-title: J. Food Safety doi: 10.1111/j.1745-4565.1977.tb00259.x – volume: 7 start-page: 50 year: 2008 ident: 10.1016/j.toxicon.2009.03.020_bib4 article-title: Different formulations of botulinum toxin type A have different migration characteristics: a double-blind, randomized study publication-title: J. Cosmet. Dermatol. doi: 10.1111/j.1473-2165.2008.00361.x – volume: 2 start-page: 3 issue: Suppl. 3 year: 1995 ident: 10.1016/j.toxicon.2009.03.020_bib1 article-title: Pharmacology of BOTOX® (botulinum toxin type A) purified neurotoxin complex: local versus systemic muscle activity measurements in mice publication-title: Eur. J. Neurol. – volume: 13 start-page: 10 issue: Suppl. 4 year: 2006 ident: 10.1016/j.toxicon.2009.03.020_bib2 article-title: Using translational medicine to understand clinical differences between botulinum toxin formulations publication-title: Eur. J. Neurol. doi: 10.1111/j.1468-1331.2006.01649.x – volume: 9 start-page: 17 issue: Suppl. 1 year: 2007 ident: 10.1016/j.toxicon.2009.03.020_bib5 article-title: Diffusion characteristics of botulinum neurotoxin products and their clinical significance in cosmetic applications publication-title: J. Cosmet. Laser Ther. doi: 10.1080/17429590701523794 – volume: 43 start-page: 4791 year: 2004 ident: 10.1016/j.toxicon.2009.03.020_bib25 article-title: Enhancement of the endopeptidase activity of purified botulinum neurotoxins A and E by an isolated component of the native neurotoxin associated proteins publication-title: Biochemistry doi: 10.1021/bi0355544 – volume: 42 start-page: 461 year: 2003 ident: 10.1016/j.toxicon.2009.03.020_bib26 article-title: Intramuscular injection of 125I-botulinum neurotoxin complex versus 125I-botulinum-free neurotoxin: time course of tissue distribution publication-title: Toxicon doi: 10.1016/S0041-0101(03)00196-X – volume: 20 start-page: 32 issue: Suppl. 3 year: 2007 ident: 10.1016/j.toxicon.2009.03.020_bib3 article-title: Migration characteristics of botulinum neurotoxins publication-title: Cosmet. Dermatol. – volume: 170 start-page: 59 year: 1855 ident: 10.1016/j.toxicon.2009.03.020_bib8 article-title: Ueber diffusion publication-title: Ann. Phys. doi: 10.1002/andp.18551700105 – volume: 143 start-page: 1447 year: 2007 ident: 10.1016/j.toxicon.2009.03.020_bib13 article-title: A randomized, double-blind study of the effect of Botox and Dysport/Reloxin on forehead wrinkles and electromyographic activity publication-title: Arch. Dermatol. doi: 10.1001/archderm.143.11.1447-b – year: 2007 ident: 10.1016/j.toxicon.2009.03.020_bib11 article-title: Botulinum toxin: from menace to medicine – volume: 365 start-page: R20 issue: Suppl. 2 year: 2002 ident: 10.1016/j.toxicon.2009.03.020_bib9 article-title: In vitro stability of botulinum toxin complex preparations at physiological pH and temperature publication-title: Naunyn-Schmeideberg'S Arch. Pharmacol. – volume: 33 start-page: 327 year: 2008 ident: 10.1016/j.toxicon.2009.03.020_bib18 article-title: Comparison of type A botulinum toxin products in clinical use publication-title: J. Clin. Pharm. Ther. doi: 10.1111/j.1365-2710.2008.00904.x – volume: 13 start-page: 2 issue: Suppl. 1 year: 2006 ident: 10.1016/j.toxicon.2009.03.020_bib20 article-title: Pharmacology of botulinum toxin: differences between type A preparations publication-title: Eur. J. Neurol. doi: 10.1111/j.1468-1331.2006.01438.x – volume: 33 start-page: S37 issue: Suppl. 1 year: 2007 ident: 10.1016/j.toxicon.2009.03.020_bib6 article-title: Pilot study comparing the diffusion of two formulations of botulinum toxin type A inpatients with forehead hyperhidrosis publication-title: Dermatol. Surg. doi: 10.1111/j.1524-4725.2006.32330.x – volume: 34 start-page: 1 year: 2007 ident: 10.1016/j.toxicon.2009.03.020_bib12 article-title: A randomized pilot study comparing the action halos of two commercial preparations of botulinum toxin Type A publication-title: Dermatol. Surg. doi: 10.1111/j.1524-4725.2007.34008.x – volume: 344 start-page: 474 year: 1994 ident: 10.1016/j.toxicon.2009.03.020_bib16 article-title: Dose standardization of botulinum toxin publication-title: Lancet doi: 10.1016/S0140-6736(94)91806-6 |
| SSID | ssj0003896 |
| Score | 2.121138 |
| SecondaryResourceType | review_article |
| Snippet | The pharmacological properties of Dysport
® that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the... The pharmacological properties of Dysport that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 683 |
| SubjectTerms | Animal poisons toxicology. Antivenoms Bacterial Toxins - chemistry Bacterial Toxins - pharmacokinetics Bacterial Toxins - pharmacology Bacteriology Biological and medical sciences Botulinum toxin Botulinum toxin complex Botulinum toxin Type A Botulinum Toxins, Type A - chemistry Botulinum Toxins, Type A - pharmacokinetics Botulinum Toxins, Type A - pharmacology Complex size Diffusion Diffusion of toxin Dissociation Dysport Fundamental and applied biological sciences. Psychology Medical sciences Microbiology Neuromuscular Agents - chemistry Neuromuscular Agents - pharmacokinetics Neuromuscular Agents - pharmacology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Protein Conformation Spread Structure-Activity Relationship Toxicology |
| Title | Dysport ®: Pharmacological properties and factors that influence toxin action |
| URI | https://dx.doi.org/10.1016/j.toxicon.2009.03.020 https://www.ncbi.nlm.nih.gov/pubmed/19332087 https://www.proquest.com/docview/734016827 |
| Volume | 54 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fT9swELcYvCBNE4OxdUDlh4kn0jq24yS8VTBUmFTtASTerDhxtKItrWiQ1pd9pH2IfbLd2U4L0iYkXpM4se8u98e--x0hn8pUmRzMTpTalEVSJaAHwSpHRpisjK1VvHBZvhM1vpFXt8ntBjnramEwrTLofq_TnbYOV4aBmsP5dIo1vjJGhDSWY2c5LLPa4iJXINpbo8sv48lKIYNNVv6gGSNnFq8LeYZ3g3b2c4qRp0euFAOGnb__baJez4sFEK72HS_-75I603SxQ94En5KO_LTfkg3b7JK9UQPx9I8lPaYuy9Ntn--S468eq3p5Qq_XpVeLE_fYCsV6uUcm50sX8dI_v08f30Km0jlu4d8jFistmoqGpj20_Va0dNq1PaG46Ib6yol35Obi8_XZOArNF6JS5LKNVC0t4zZLLKgAUELGIDahjbnhohbgdhVlAuFamsSlUbUwAuIYmxS8rritMx6LfbLZzBr7gdDEMMTg4byqKxlzXlhp8XWmqiVqgR6RHb11GZDJsUHGd92loN3pwCbsmplrJjSwqUcGq2FzD83x3ICsY6Z-ImMazMdzQ_tPmL_6IOcMEf5gDbSTBg0_KJ66FI2dPSx0KiCEVUCpHnnvpWQ921wIzrL048sndkC23fmWSy88JJvt_YM9AjepNX3yavAr7oef4S_m7xKI |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB5V5UClCkFbYAsUH1BPza5jO3_cqkK1QLvqYSv1ZsWJo-4KsqtuKnUvPBIPwZMxYye7VAJV6jWJE2fG82fPfAPwoUhik6HZCRKb8EDFEepBtMqBkSYtQmtjkbss31E8vFRfr6KrDTjpamEorbLV_V6nO23dXhm01BzMJxOq8VUhIaTxjDrLUZnVE4XiS9LZ_7nO80CLHPtjZoqbebgu4xlM-83sbkJxp8etlH1Ofb__baC25_kCyVb5fhf_d0idYTp9Ds9aj5Id-0m_gA1b78DucY3R9I8lO2Qux9Ntnu_A4YVHql4esfG68Gpx5B5bYVgvd2H0aeniXfb718e_bxFL2Zw28G8IiZXldcnalj2suc4bNumanjD66Zr5uok9uDz9PD4ZBm3rhaCQmWqCuFKWC5tGFhUAqiBjCJnQhsIIWUl0uvIiwmAticLCxJU0EqMYG-WiKoWtUhHKl7BZz2r7GlhkOCHwCFFWpQqFyK2y9DpTVop0QA9UR29dtLjk1B7ju-4S0Ka6ZRP1zMw0lxrZ1IP-atjcA3M8NCDtmKnvrTCNxuOhoQf3mL_6oBCc8P3wH1i3GjSKJ5255LWd3S50IjGAjZFSPXjlV8l6tpmUgqfJ_uMn9h6eDsfnZ_rsy-jbG9hyJ10u0fAtbDY3t_YdOkyNOXAC8QcqgRNM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=Toxicon+%28Oxford%29&rft.atitle=Dysport%C2%AE%3A+Pharmacological+properties+and+factors+that+influence+toxin+action&rft.au=PICKETT%2C+Andy&rft.date=2009-10-01&rft.pub=Elsevier&rft.issn=0041-0101&rft.volume=54&rft.issue=5&rft.spage=683&rft.epage=689&rft_id=info:doi/10.1016%2Fj.toxicon.2009.03.020&rft.externalDBID=n%2Fa&rft.externalDocID=22063565 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0041-0101&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0041-0101&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0041-0101&client=summon |