Dysport ®: Pharmacological properties and factors that influence toxin action

• Published in: Toxicon (Oxford) Vol. 54; no. 5; pp. 683 - 689
• Main Author: Pickett, Andy
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier Ltd 01.10.2009; Elsevier
• Subjects: Animal poisons toxicology. Antivenoms; Bacterial Toxins - chemistry; Bacterial Toxins - pharmacokinetics; Bacterial Toxins - pharmacology; Bacteriology; Biological and medical sciences; Botulinum toxin; Botulinum toxin complex; Botulinum toxin Type A; Botulinum Toxins, Type A - chemistry; Botulinum Toxins, Type A - pharmacokinetics; Botulinum Toxins, Type A - pharmacology; Complex size; Diffusion; Diffusion of toxin; Dissociation; Dysport; Fundamental and applied biological sciences. Psychology; Medical sciences; Microbiology; Neuromuscular Agents - chemistry; Neuromuscular Agents - pharmacokinetics; Neuromuscular Agents - pharmacology; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Protein Conformation; Spread; Structure-Activity Relationship; Toxicology; Botulinum toxin complex; Complex size; Spread; Dysport; Diffusion of toxin; Dissociation; Botulinum toxin; Botulinum toxin Type A; Enzyme; Metalloendopeptidases; Biological activity; Peptidases; Toxin; Bontoxilysin; Hydrolases; Diffusion
• ISSN: 0041-0101; 1879-3150; 1879-3150
• DOI: 10.1016/j.toxicon.2009.03.020

The pharmacological properties of Dysport ® that influence toxin action are reviewed and compared with other botulinum toxin products. In particular, the subject of diffusion is examined and discussed based upon the evidence that currently exists, both from laboratory studies and from clinical data. Diffusion of botulinum toxin products is not related to the size of the toxin complex in the product since the complex dissociates under physiological conditions, releasing the naked neurotoxin to act. The active neurotoxin in Type A products is the same and therefore diffusion is equal when equal doses are administered.