The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer

• Published in: Journal of obstetrics and gynaecology Vol. 40; no. 6; p. 856
• Main Authors: Yilmaz, Ercan, Melekoglu, Rauf, Taskapan, Cagatay, Olmez Budak, Fatma, Toprak, Serhat
• Format: Journal Article
• Language: English
• Published: England 17.08.2020
• Subjects: ADAMTS Proteins - blood; ADAMTS5 Protein - blood; Adult; Aged; Carcinoma, Endometrioid - blood; Carcinoma, Endometrioid - etiology; Case-Control Studies; Endometrial Neoplasms - blood; Endometrial Neoplasms - etiology; Endometrium - metabolism; Female; Humans; Middle Aged; endometrial cancer; ADAMTS5; tumourigenesis; ADAMTS8; chronic inflammation
• ISSN: 1364-6893
• DOI: 10.1080/01443615.2019.1674265

The aim of this study was to investigate the serum levels of the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 5 and 8 in patients diagnosed with endometrial cancer. Our study included 41 patients diagnosed with endometrial cancer. The control group consisted of 41 patients diagnosed with benign endometrial pathology. The serum samples were centrifuged and stored at -80 °C. The serum levels of ADAMTS were significantly higher ( <.001), whereas the levels of ADAMTS 8 were significantly lower in patients diagnosed with cancer ( <.001). In addition to the presence of known factors in the aetiology of endometrial cancer, the effect of inflammatory factors and some new proteins has centred on the causes of tumourigenesis in recent years. In this sense, these proteins, called the ADAMTS, are the source of new studies.Impact Statement When the recent studies about endometrial cancer are evaluated, it is seen that the effects of chronic inflammation and cytokines have gained importance in its aetiology. The A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) gene family consist of 19 proteases that play essential role in the formation of the extracellular matrix (ECM) and interact with inflammatory cytokines. These proteases and their substrates provide a wide range of functions in different tissues, including ECM remodelling, angiogenesis, fibrosis and coagulation. ADAMTS 5, which causes the degradation of the ECM with Aggrecanase activity, was found to be significantly higher in patients diagnosed with cancer and ADAMTS 8 with anti-angiogenesis activity was significantly lower in patients diagnosed with endometrial cancer. In this study, it is understood that the effect of inflammatory mediators is remarkably important in the aetiology of endometrial cancer, as in many types of organ specific cancer.