Introducing a flexible drug delivery system based on poly(glycerol sebacate)-urethane and its nanocomposite: potential application in the prevention and treatment of oral diseases

• Published in: Journal of biomaterials science. Polymer ed. Vol. 33; no. 4; pp. 443 - 464
• Main Authors: Tirgar, Mahtab, Hosseini, Hadi, Jafari, Milad, Shojaei, Shahrokh, Abdollahi, Amir, Jafari, Aliakbar, Uzun, Lokman, Goodarzi, Vahabodin, Su, Chia-Hung
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.03.2022; Taylor & Francis Ltd
• Subjects: bionanocomposite; Clay; Cloisite@30B; Decanoates - chemistry; drug delivery; Drug Delivery Systems; Glycerol; Glycerol - analogs & derivatives; Glycerol - chemistry; Gum disease; Metronidazole; Nanocomposites; Nanocomposites - chemistry; Poly(glycerol sebacic)-urethane; Polymers; Tetracycline; Tissue engineering; Urethane; Poly(glycerol sebacic)-urethane; bionanocomposite; tissue engineering; drug delivery; gum disease; Cloisite@30B
• ISSN: 0920-5063; 1568-5624
• DOI: 10.1080/09205063.2021.1992588

In this study, a novel biopolymer based on poly(glycerol sebacic)-urethane (PGS-U) and its nanocomposites containing Cloisite@30B were synthesized by facile approach in which the crosslinking was created by aliphatic hexamethylene diisocyanate (HDI) at room temperature and 80 °C. Moreover, metronidazole and tetracycline drugs were selected as target drugs and loaded into PGSU based nanocomposites. A uniform and continuous microstructure with smooth surface is observed in the case of pristine PGS-U sample. The continuity of microstructure is observed in the case of all bionanocomposites. XRD result confirmed an intercalated morphology for PGSU containing 5 wt% of clay nanoparticles with a d-spacing 3.4 nm. The increment of nanoclay content up to 5%, the ultimate tensile stress and elastic modulus were obtained nearly 0.32 and 0.83 MPa, which the latter was more than eight-fold than that of pristine PGS-U. A sustained release for both dugs was observed by 200 h. The slowest and controlled drug release rate was determined in the case of PGSU containing 5 wt% clay and cured at 80 °C. A non-Fickian diffusion can be concluded in the case of tetracycline release via PGS-U/nanoclay bionanocomposites, while a Fickian process was detected in the case of metronidazole release by PGS-U/nanoclay bionanocomposites. As a result, the designed scaffold showed high flexibility, which makes it an appropriate option for utilization in the treatment of periodontal disease.