Ultra-sensitive polysilicon wire glucose sensor using a 3-aminopropyltriethoxysilane and polydimethylsiloxane-treated hydrophobic fumed silica nanoparticle mixture as the sensing membrane

• Published in: Sensors and actuators. B, Chemical Vol. 142; no. 1; pp. 273 - 279
• Main Authors: Hsu, Po-Yen, Lin, Jing-Jenn, Wu, You-Lin, Hung, Wen-Chang, Cullis, A.G.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 12.10.2009
• Subjects: Capillary atomic-force-microscope tip; Focus-ion-beam; Polysilicon wire; Silica nanoparticles; Ultraviolet light; Silica nanoparticles; Capillary atomic-force-microscope tip; Ultraviolet light; Polysilicon wire; Focus-ion-beam
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2009.08.003

In this paper a highly sensitive glucose biosensor is proposed based on a polysilicon (poly-Si) wire structure coated with 3-aminopropyltriethoxysilane (γ-APTES) mixed with polydimethylsiloxane-treated hydrophobic fumed silica nanoparticles (NPs) as the sensing membrane. The γ-APTES and fumed silica NPs mixture was directly transferred to and coated onto the poly-Si wire region with the help of a focus-ion-beam (FIB) processed capillary atomic-force-microscope (C-AFM) tip. After the necessary curing and UV illumination processes, the resultant sensor showed an extremely wide linear detection range from 0.1 μM to 10 mM with a channel current sensitivity as high as 5.33 A mM −1 cm −2 (or a channel conductance sensitivity of 70 μS mM −1), and a detection limit as low as 10 nM can be achieved. Our experimental results showed that the poly-Si wire sensor has good selective analysis and operational stability on glucose detection under a 10:1 concentration ratio of glucose and uric acid. Its linear range and lowest detection limit remain virtually unimpaired in the presence of uric acid.