Synthesis of the impurity F of salbutamol

First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2% total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further ana...

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Bibliographic Details
Published inJournal of asian natural products research Vol. 22; no. 10; pp. 956 - 965
Main Authors Song, Shu-Lian, Lian, Cheng-Xi, Chen, Li-Ping, Huang, Long-Jiang
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 02.10.2020
Taylor & Francis Ltd
Subjects
Chemistry
Chemistry, Applied
Chemistry, Medicinal
Impurities
impurity F
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Salbutamol
Science & Technology
Synthesis
Toxicology
synthesis
Salbutamol
SULFATE
impurity F
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Summary:First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2% total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further analytical and toxicology investigations.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1771700