Anti-inflammatory xanthone derivatives from Garcinia delpyana

• Published in: Journal of asian natural products research Vol. 23; no. 5; pp. 414 - 422
• Main Authors: Nhan, Ngu-Truong, Nguyen, Phi-Hung, Tran, Manh-Hung, Nguyen, Phuong-Dai-Nguyen, Tran, Dang-Thach, To, Dao-Cuong
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 04.05.2021; Taylor & Francis Ltd
• Subjects: Animals; anti-inflammatory; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Bark; Chemistry; Chemistry, Applied; Chemistry, Medicinal; delpyxanthone A; delpyxanthone B; Garcinia; Garcinia delpyana; Inflammation; Life Sciences & Biomedicine; Lipopolysaccharides; Mass spectrometry; Mass spectroscopy; Mice; Molecular Structure; Nitric oxide; NMR; Nuclear magnetic resonance; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; RAW 264.7 Cells; Science & Technology; stem bark; xanthone; Xanthones - pharmacology; PLANT; stem bark; ANTIBACTERIAL ACTIVITY; delpyxanthone A; PHENOLIC-COMPOUNDS; delpyxanthone B; anti-inflammatory; EXTRACTS; Garcinia delpyana; xanthone
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2020.1767079

Two new xanthones delpyxanthone A (1) and delpyxanthone B (3), together with four known ones, gerontoxanthone I (2), α-mangostin (4), cowanin (5) and cowanol (6) were isolated from the stem bark of Garcinia delpyana. The chemical structures of 1-6 were established mainly using nuclear magnetic resonance (NMR) and mass spectrometry (MS). The anti-inflammatory activity of the isolated compounds was evaluated against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells in vitro. Compounds 1-4 showed significant inhibitory activity against the LPS-induced NO production in RAW264.7 cells with IC 50 values ranging from 14.5 to 28.2 μM, but the others were inactive. The results suggested that G. delpyana and its constituents might be potential anti-inflammatory agents on RAW 264.7 cells.