Brain kinetics of the new selective serotonin transporter tracer [ 123I]ADAM in healthy young adults

• Published in: Nuclear medicine and biology Vol. 33; no. 2; pp. 185 - 191
• Main Authors: Booij, Jan, de Win, Maartje M.L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2006
• Subjects: [ 123I]ADAM; Adult; Brain - diagnostic imaging; Brain - metabolism; Brain kinetics; Cinanserin - analogs & derivatives; Cinanserin - pharmacokinetics; Female; Human; Humans; Kinetics; Male; Metabolic Clearance Rate; Organ Specificity; Radiopharmaceuticals - pharmacokinetics; Reference Values; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter imaging; SPECT; Tissue Distribution; Tomography, Emission-Computed, Single-Photon - methods; Human; [ 123I]ADAM; Brain kinetics; Serotonin transporter imaging; SPECT
• ISSN: 0969-8051; 1872-9614
• DOI: 10.1016/j.nucmedbio.2005.10.005

Recently, the tracer 123I-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine ([ 123I]ADAM) has been developed for selective imaging of serotonin transporters (SERTs) with single photon emission computed tomography (SPECT). The purpose of this study was to develop an [ 123I]ADAM SPECT protocol for clinical studies in young adults. We examined the time course of [ 123I]ADAM binding to central SERTs in eight healthy young volunteers up to 6 h postinjection. We found that the time of peak-specific [ 123I]ADAM binding was highly variable among subjects, but specific binding in the SERT-rich (hypo)thalamus peaked within 5 h postinjection in all subjects. Moreover, in this brain area, binding ratios of specific to nonspecific binding did not significantly change between 3 and 6 h postinjection, and peaked 5 h postinjection. Five hours postinjection may be optimal for single-scan [ 123I]ADAM SPECT studies in humans, but more work is needed to assess the accuracy of the 5-h tissue ratio as a measure of SERT in the brain.