Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom

• Published in: Natural product research Vol. 34; no. 24; pp. 3437 - 3443
• Main Authors: Yang, Yong-Cheng, Wang, Yan-Ming, Rong, Zi-Jian, Hong, Li-Na, Zhang, Qian, Jia, Jing-Ming, Wang, An-Hua
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 16.12.2020; Taylor & Francis Ltd
• Subjects: 5-Fluorouracil; Alkaloids; Alkaloids - chemistry; Alkaloids - pharmacology; Anticancer properties; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; antitumor; antofine; benzene derivative; Cell Line, Tumor; Cynanchum; Cynanchum - chemistry; Cynanchum mongolicum; cytotoxicity; Drug Screening Assays, Antitumor; Esters; Humans; Indoles - chemistry; Indoles - pharmacology; Molecular Structure; Phenanthrolines - chemistry; Phenanthrolines - pharmacology; Phytochemicals - chemistry; Phytochemicals - pharmacology; Tumor cell lines; benzene derivative; antitumor; Cynanchum mongolicum; cytotoxicity; antofine
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2019.1574787

A chemical investigation of Cynanchum mongolicum (Maxim.) Kom. identified 8 compounds. On the basis of spectroscopic data, they were determined to be 3 alkaloids and 5 sinapoyl esters, among which were two previously undescribed compounds (1 and 2). The inhibitory effects of the isolated compounds against four human tumor cell lines were evaluated in vitro by MTT assays, which revealed moderate inhibitory effects with IC 50 values < 50 mM, in particularly, three antofine analogues have showed significant antitumor activities with IC 50 values < 0.1 mM, which was obviously better than the 5-fluorouracil and potential to be used as cancer drugs.