Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Head and Neck Squamous Cell Carcinoma

• Published in: Annals of otology, rhinology & laryngology Vol. 106; no. 4; pp. 271 - 278
• Main Authors: Charous, Steven J., Stricklin, George P., Netterville, James L., Nanney, Lillian B., Burkey, Brian B.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.1997; Annals Publishing Compagny; SAGE PUBLICATIONS, INC
• Subjects: Adult; Aged; Biological and medical sciences; Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Collagenases - metabolism; DNA Primers; Gelatinases - metabolism; Gene Amplification; Gene Expression; Glycoproteins - metabolism; Head and Neck Neoplasms - enzymology; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Histocytochemistry; Humans; In Situ Hybridization; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Medical sciences; Metalloendopeptidases - biosynthesis; Metalloendopeptidases - metabolism; Middle Aged; Neoplasm Staging; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinases; Tumors; TEMP; metalloproteinase; tissue inhibitor of metalloproteinase; squamous cell carcinoma; Human; Molecular hybridization; Squamous cell carcinoma; Pathogenesis; In situ; Malignant tumor; Metastasis; Metalloproteins; Head and neck; Genetics; ENT disease; Complication; Extracellular matrix; Molecular biology; Bibliographic review
• ISSN: 0003-4894; 1943-572X
• DOI: 10.1177/000348949710600402

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes implicated in the invasion and metastasis of many cancers. In situ hybridization techniques were used to reveal sites of expression of collagenase (MMP-1), gelatinase 72 kd (MMP-2), gelatinase 92 kd (MMP-9), and tissue inhibitor of metalloproteinase-1 (TTMP-1) in head and neck carcinomas (N=21). Both TTMP-1 and gelatinase 72 kd were expressed in nearly all tumors, whereas the expression of collagenase and gelatinase 92 kd showed variability. Tumor-associated expression of MMPs was strongest in stromal cells near advancing margins. No differences in expression levels were detected between primary and metastatic sites. This paper reviews the literature and discusses the significance and possible implications of MMPs in head and neck squamous cell carcinoma.