Synthesis and antioxidant activity of curcumin analogs

Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This r...

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Published inJournal of asian natural products research Vol. 19; no. 5; pp. 489 - 503
Main Authors Zheng, Qu-Tong, Yang, Ze-Hua, Yu, Liu-Ying, Ren, Yu-Yan, Huang, Qiu-Xia, Liu, Qiu, Ma, Xiang-Yu, Chen, Zi-Kang, Wang, Zong-Bao, Zheng, Xing
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.05.2017
Taylor & Francis Ltd
Subjects
antioxidant activity
Antioxidants
Antioxidants - chemical synthesis
Antioxidants - chemistry
Antioxidants - pharmacology
Curcumin
Curcumin - analogs & derivatives
Curcumin - chemical synthesis
Curcumin - chemistry
Curcumin - pharmacology
Humans
Molecular Structure
structure modification
Structure-Activity Relationship
structure–activity relationship
structure modification
Curcumin
antioxidant activity
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Summary:Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure-activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2016.1235562