Protective Effect of Dermorphin Analogue Sedatin on Indomethacin-Induced Injury to the Gastric Mucosa
Administration of indomethacin (250 mg/kg) to mice was followed by the formation of severe ulcerative and erosive injury to the gastric mucosa, inhibition of DNA synthesis, and development of oxidative stress. Fivefold pretreatment with sedatin (100 μg/kg) decreased the area of indomethacin-induced...
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Published in | Bulletin of experimental biology and medicine Vol. 148; no. 1; pp. 60 - 63 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Boston : Springer US
01.07.2009
Springer US Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Administration of indomethacin (250 mg/kg) to mice was followed by the formation of severe ulcerative and erosive injury to the gastric mucosa, inhibition of DNA synthesis, and development of oxidative stress. Fivefold pretreatment with sedatin (100 μg/kg) decreased the area of indomethacin-induced ulcers and erosions, stimulated DNA synthesis, and reduced the severity of oxidative stress. Non-arginine dermorphin analogue did not stimulate DNA synthesis and had no effect on the degree of oxidative stress. After pretreatment with L-NAME, sedatin did not modulate the synthesis of DNA under conditions of indomethacin-induced injury to the gastric mucosa. |
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Bibliography: | http://dx.doi.org/10.1007/s10517-009-0621-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-4888 1573-8221 |
DOI: | 10.1007/s10517-009-0621-0 |