Usneaceratins A and B, two new secondary metabolites from the lichen Usnea ceratina

Two new compounds, comprising one dibenzofuran, named usneaceratin A (1), and one phenolic acid, named usneaceratin B (2), together with one known dibenzofuran, isousnic acid (3), and two known phenolics, orsellinic acid (4) and methyl orsellinate (5) were clarified from the lichen Usnea ceratina us...

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Published inNatural product research Vol. 36; no. 15; pp. 3945 - 3950
Main Authors Bui, Van Muoi, Huynh, Bui Linh Chi, Pham, Nguyen Kim Tuyen, Nguyen, Thi Anh Tuyet, Nguyen, Thi Thuy Trang, Nguyen, Kim Phi Phung, Nguyen, Tan Phat
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.08.2022
Taylor & Francis Ltd
Subjects
Acarbose
Chromatography
Dibenzofuran
Glucosidase
Lichens
Metabolites
NMR
Nuclear magnetic resonance
phenolic
Phenolic acids
Phenols
Secondary metabolites
Usnea ceratina
usneaceratin
α-Glucosidase
α-glucosidase inhibitory activity
dibenzofuran
α-glucosidase inhibitory activity
Usnea ceratina
phenolic
usneaceratin
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Summary:Two new compounds, comprising one dibenzofuran, named usneaceratin A (1), and one phenolic acid, named usneaceratin B (2), together with one known dibenzofuran, isousnic acid (3), and two known phenolics, orsellinic acid (4) and methyl orsellinate (5) were clarified from the lichen Usnea ceratina using variously chromatographic methods. Their structures were testified by comprehensive HR-ESI-MS, and NMR spectroscopic analysis, and comparison with published data. Their α-glucosidase inhibitory activity of all compounds was measured. Usneaceratin B (2) possessed better inhibition against α-glucosidase enzyme (IC 50 value of 41.8 μM) than the standard drug acarbose (IC 50 value of 214.50 μM).
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1901288