Determination of 105 antibiotic, anti-inflammatory, antiparasitic agents and tranquilizers by LC-MS/MS based on an acidic QuEChERS-like extraction

A procedure for screening 105 veterinary drugs in foods by liquid chromatography tandem mass-spectrometry (LC-MS/MS) is presented. Its scope encompasses raw materials of animal origin (milk, meat, fish, egg and fat) but also related processed ingredients and finished products commonly used and manuf...

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Published inFood additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Vol. 35; no. 4; pp. 647 - 661
Main Authors Desmarchelier, Aurélien, Fan, Kaïli, Minh Tien, Mai, Savoy, Marie-Claude, Tarres, Adrienne, Fuger, Denis, Goyon, Alexandre, Bessaire, Thomas, Mottier, Pascal
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.04.2018
Taylor & Francis Ltd
Subjects
Antibiotics
Antiparasitic agents
dairy ingredients
Drug screening
Drugs
egg
fat
fish
Fish eggs
Food
Food matrix
infant formula
Inflammation
Ionization
Laboratories
LC-MS/MS
Liquid chromatography
Meat
milk
Quality control
QuEChERS
Raw materials
Ruggedness
Screening
Spectrometry
standard addition
Tranquilizers
Veterinary drugs
Veterinary medicine
LC-MS/MS
standard addition
screening
egg
Veterinary drugs
dairy ingredients
infant formula
QuEChERS
fish
fat
meat
milk
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Summary:A procedure for screening 105 veterinary drugs in foods by liquid chromatography tandem mass-spectrometry (LC-MS/MS) is presented. Its scope encompasses raw materials of animal origin (milk, meat, fish, egg and fat) but also related processed ingredients and finished products commonly used and manufactured by food business operators. Due to the complexity of the matrices considered and to efficiently deal with losses during extraction and matrix effects during MS source ionisation, each sample was analysed twice, that is 'unspiked' and 'spiked at the screening target concentration' using a QuEChERS-like extraction. The entire procedure was validated according to the European Community Reference Laboratories Residues Guidelines. False-negative and false-positive rates were below 5% for all veterinary drugs whatever the food matrix. Effectiveness of the procedure was further demonstrated through participation to five proficiency tests and its ruggedness demonstrated in quality control operations by a second laboratory.
Bibliography:ObjectType-Article-1
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ISSN:1944-0049
1944-0057
DOI:10.1080/19440049.2018.1429677