Regulation of peripheral B cell maturation

Although it is clear that the final phases of B cell maturation occur after newly formed B cells exit the bone marrow, the mechanisms underpinning the maturation, selection, and long-term survival of immature peripheral B cells remain poorly understood. Here, we review recent advances in our underst...

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Bibliographic Details
Published inCellular Immunology Vol. 239; no. 2; pp. 92 - 102
Main Authors Thomas, Matthew D., Srivastava, Bhaskar, Allman, David
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.02.2006
Subjects
Animals
B cells
B-Lymphocyte Subsets - cytology
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Cell Differentiation - immunology
Differentiation
Homeostasis
Humans
Maturation
Receptors, Antigen, B-Cell - biosynthesis
Receptors, Antigen, B-Cell - physiology
Signal Transduction - immunology
Homeostasis
B cells
Maturation
Differentiation
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Summary:Although it is clear that the final phases of B cell maturation occur after newly formed B cells exit the bone marrow, the mechanisms underpinning the maturation, selection, and long-term survival of immature peripheral B cells remain poorly understood. Here, we review recent advances in our understanding of how B cell receptor (BCR)-mediated signaling events integrate with additional environmental cues to promote the selection and differentiation of immature B cells into functionally distinct subpopulations of mature B cells. We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0008-8749
1090-2163
1365-2567
DOI:10.1016/j.cellimm.2006.04.007