Comment on “Some immunomodulatory effects of probiotic bacteria might be due to porcine neutrophil elastase inhibitor, a serpin present in MRS broth” [Immunol. Lett. (December) (in press) 1]

Abstract Serpins that are present in MRS broth were suspected to be responsible for some of the observed immunomodulatory effects of probiotic bacteria conditioned media. Some comments on this reporting, together with considerations dealing with manipulation of spent culture media and possible inter...

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Bibliographic Details
Published inImmunology letters Vol. 122; no. 2; pp. 227 - 228
Main Authors Foligné, Benoît, Pot, Bruno
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 21.02.2009
Subjects
Aerobiosis - immunology
Allergy and Immunology
Anaerobiosis - immunology
Animals
Conditioned media
Culture Media, Conditioned - pharmacology
Fermentation - immunology
Host immunomodulation
Immunologic Factors - metabolism
MRS
Probiotic
Probiotics - metabolism
Proteinase Inhibitory Proteins, Secretory - metabolism
Reactive Oxygen Species
Serpin
Serpins - immunology
Serpins - pharmacology
Swine
Tandem Mass Spectrometry
Probiotic
Host immunomodulation
Serpin
Conditioned media
MRS
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Summary:Abstract Serpins that are present in MRS broth were suspected to be responsible for some of the observed immunomodulatory effects of probiotic bacteria conditioned media. Some comments on this reporting, together with considerations dealing with manipulation of spent culture media and possible interfering effects, are discussed.
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ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2009.01.006