Aerobic exercise training performed by parents reduces mice offspring adiposity

• Published in: Journal of sports sciences Vol. 36; no. 14; pp. 1578 - 1585
• Main Authors: Romero, Paulo Vitor da Silva, Guariglia, Débora Alves, Da Rocha, Francielli Ferreira, Picoli, Caroline de Carvalho, Gilio, Gustavo Renan, Fabricio, Gabriel Sergio, Mathias, Paulo Cesar de Freitas, Moraes, Solange Marta Franzói de, Peres, Sidney Barnabé
• Format: Journal Article
• Language: English
• Published: England Routledge 18.07.2018; Taylor & Francis Ltd
• Subjects: Adipocytes; Adipose tissue; Adiposity - genetics; Adiposity - physiology; Animals; Blood Glucose - metabolism; Body Weight - physiology; Cholesterol - blood; Cholesterol, VLDL - blood; Epigenetic; Exercise; Female; Fitness training programs; Intra-Abdominal Fat - physiology; Male; Metabolic syndrome; Metabolism; Mice; Models, Animal; Obesity; offspring; Parents & parenting; Physical Conditioning, Animal - physiology; Physical fitness; Physical training; Rodents; Sexual Behavior, Animal; Subcutaneous Fat - physiology; Triglycerides - blood; Weaning; offspring; adipose tissue; exercise; Epigenetic
• ISSN: 0264-0414; 1466-447X
• DOI: 10.1080/02640414.2017.1405474

The present study aimed to determine the effects of physical training performed by parents on mice offspring adiposity. Male and female parents underwent an aerobic training protocol for 7 weeks. The trained and sedentary parents were allowed to mate and the resultant offspring divided in: S (Offspring from Sedentary Parents), T (Offspring from Trained Parents), ST (Offspring from Sedentary Father and Trained Mother) and TS (Offspring from Trained Father and Sedentary Mother). After weaning, offspring was euthanized, blood collected and samples of mesenteric and inguinal fat pads used to isolate adipocytes for morphologic and histological analyses. Lee index, mesenteric fat pad, sum of visceral fat and total fat weight of female T was reduced in comparison to the other groups (p < 0.05). Periepididymal and sum of visceral fat in male T group was also reduced when compared to the other groups (p < 0.05). The diameter of mesenteric and inguinal adipocytes of T group was smaller compared to all groups comparisons for both sexes (p < 0.05). In summary, exercise training performed by parents reduced visceral offspring adiposity, the diameter of subcutaneous adipocytes and improved metabolic parameters associated to metabolic syndrome.