Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects

• Published in: Biomolecules & therapeutics Vol. 25; no. 6; pp. 659 - 664
• Main Authors: Yun, Jaesuk, Lee, Kwang-Wook, Eom, Jang-Hyeon, Kim, Young-Hoon, Shin, Jisoon, Han, Kyoungmoon, Park, Hye-Kyung, Kim, Hyung Soo, Cha, Hye Jin
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Applied Pharmacology 01.11.2017; 한국응용약물학회
• Subjects: Original; 약학; Self-administration; Synaptosome; Dopamine; Lisdexamfetamine; Conditioned place preference; Dependence
• ISSN: 2005-4483; 1976-9148; 1976-9148; 2005-4483
• DOI: 10.4062/biomolther.2016.080

Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and dependence profile of lisdexamfetamine using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques are used to assess alterations in the dopamine levels in striatal synaptosomes following administration of lisdexamfetamine. Lisdexamfetamine increased both conditioned place preference and self-administration. Moreover, after administration of the lisdexamfetamine, dopamine levels in the striatal synaptosomes were significantly increased. Although some modifications should be made to the analytical methods, performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future. Collectively, lisdexamfetamine has potential for dependence possible via dopaminergic pathway.