The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study

• Published in: Journal of obstetrics and gynaecology Vol. 41; no. 2; p. 263
• Main Authors: Ekin, Murat, Kaya, Cihan, Erdoğan, Şakir Volkan, Bahçeci, Ece, Baghaki, Sema, Yaşar, Levent
• Format: Journal Article
• Language: English
• Published: England 17.02.2021
• Subjects: Adult; Dysmenorrhea - etiology; Dysmenorrhea - prevention & control; Dyspareunia - etiology; Dyspareunia - prevention & control; Endometriosis - pathology; Endometriosis - psychology; Endometriosis - surgery; Female; Gels; Humans; Hyaluronic Acid - administration & dosage; Laparoscopy - adverse effects; Laparoscopy - methods; Pilot Projects; Postoperative Complications - physiopathology; Postoperative Complications - prevention & control; Postoperative Complications - psychology; Quality of Life; Severity of Illness Index; Tissue Adhesions - etiology; Tissue Adhesions - prevention & control; Treatment Outcome; Viscosupplements - administration & dosage; Visual Analog Scale; Endometriosis; tissue adhesions; quality of life; adhesion barriers; hyaluronic acid
• ISSN: 1364-6893
• DOI: 10.1080/01443615.2020.1755628

In this prospective randomised placebo-controlled study, we aimed to evaluate the effect of New Cross linked Hyaluronan Gel (NCH gel) on the quality of life of patients who underwent laparoscopic surgery due to Deep Infiltrating Endometriosis (DIE). The intervention group received 40 mL of NCH gel, and the control group had a 40 mL sterile saline solution instilled into the peritoneal cavity following standard laparoscopic procedures. The patients were called in the third and sixth postoperative months and requested to fill the Visual Analogue Scale (VAS), Endometriosis Health Profile (EHP-5), and Short Form for Mental and Physical Health (SF-12) questionnaires. There was a significant reduction in dysmenorrhoea, dyschezia, dyspareunia VAS scores at 3rd, and 6th-month visits in NCH gel group. The postoperative 6th-month EHP-5 scores were significantly lower (1.16 ± 1.51, -value: .02) in NCH gel group. Besides, NCH gel group had higher SF-12 mental and SF-12 physical scores. NCT04023383IMPACT STATEMENT Application of solid or liquid physical barriers is believed to be a promising strategy to reduce adhesions after laparoscopic endometriosis surgery. However, comparable data regarding the effects of adhesion barriers are still lacking. We revealed that there was a significantly higher decrease in VAS and EHP-5 scores and an increase in SF-12 physical-mental ratings after surgery in NCH gel group. Using NHC gel in addition to standard surgical procedure improves postoperative VAS scores, and provides better quality of life scores.